ArticleFrontiers in cellular neuroscience2016
How to Properly Measure a Current-Voltage Relation?-Interpolation vs. Ramp Methods Applied to Studies of GABAA Receptors.
Article in Frontiers in cellular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Chloride Homeostasis in Neuronal Disorders: Bridging Measurement to Therapy.Life (Basel, Switzerland) · 2025Review
- Optogenetic Determination of Dynamic and Cell-Type-Specific Inhibitory Reversal Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spatiotemporal Mapping and Molecular Basis of Whole-brain Circuit Maturation.bioRxiv : the preprint server for biology · 2024Article
- The Electrical Response of Real Dielectrics: Using the Voltage Ramp Method as a Straightforward Diagnostic Tool for Polymeric Composites.Materials (Basel, Switzerland) · 2022Article
- Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional outcome after stroke.Acta neuropathologica communications · 2019Article
- Whole-GUV patch-clamping.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Commentary: Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.Frontiers in cellular neuroscience · 2016Article
- Synaptic Conductances during Interictal Discharges in Pyramidal Neurons of Rat Entorhinal Cortex.Frontiers in cellular neuroscience · 2016Article
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Abstract
The relation between current and voltage, I-V relation, is central to functional analysis of membrane ion channels. A commonly used method, since the introduction of the voltage-clamp technique, to establish the I-V relation depends on the interpolation of current amplitudes recorded at different steady voltages. By a theoretical computational approach as well as by experimental recordings from GABAA-receptor mediated currents in mammalian central neurons, we here show that this interpolation method may give reversal potentials and conductances that do not reflect the properties of the channels studied under conditions when ion flux may give rise to concentration changes. Therefore, changes in ion concentrations may remain undetected and conclusions on changes in conductance, such as during desensitization, may be mistaken. In contrast, an alternative experimental approach, using rapid voltage ramps, enable I-V relations that much better reflect the properties of the studied ion channels.
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