ReviewDialogues in clinical neuroscience2015
Emotional and cognitive dysregulation in schizophrenia and depression: understanding common and distinct behavioral and neural mechanisms.
Review in Dialogues in clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Effect of mGluR2 positive allosteric modulation on frontostriatal working memory activation in schizophrenia.Molecular psychiatry · 2022Trial
- Understanding Anticipatory Anhedonia in Schizophrenia and Depression: Linking Reward Representation Maintenance from a Transdiagnostic Perspective.Schizophrenia bulletin · 2026Article
- Uncovering oscillatory dysregulation associated with suicide risk in major depressive disorder: a narrative review.Translational psychiatry · 2026Review
- History, Challenges, and Perspectives of CNS-Targeted Transdermal Formulations.Current pharmaceutical design · 2026Review
- Ultra-high Field fMRI Reveals Effect of Ketamine on Vocal Processing in Common Marmosets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Altered dynamic functional and effective connectivity in drug-naive children with Tourette syndrome.Translational psychiatry · 2024Article
- Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia.Brain sciences · 2023Article
- The effects of social isolation stress and discrimination on mental health.Translational psychiatry · 2022Review
- Resting-state functional connectivity of salience network in schizophrenia and depression.Scientific reports · 2022Article
- Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signals.NeuroImage · 2022Article
- Altered brain functional network dynamics in obsessive-compulsive disorder.Human brain mapping · 2021Article
- Altered Functional Connectivity of the Nucleus Accumbens Network Between Deficit and Non-deficit Schizophrenia.Frontiers in psychiatry · 2021Article
- Genome-wide association study of antipsychotic-induced sinus bradycardia in Chinese schizophrenia patients.PloS one · 2021Article
- Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model.Frontiers in neuroscience · 2020Article
- Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium.NeuroImage. Clinical · 2020Article
- The role of hedonics in the Human Affectome.Neuroscience and biobehavioral reviews · 2019Review
- Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders.Journal of psychiatric research · 2019Article
- Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults.Human brain mapping · 2018Article
- Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?-A Perspective Paper.Frontiers in psychiatry · 2018Article
- Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia.Translational neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Emerging behavioral and neuroimaging studies in schizophrenia (SCZ) and major depressive disorder (MD) are mapping mechanisms of co-occurring and distinct affective disturbances across these disorders. This constitutes a critical goal towards developing rationally guided therapies for upstream neural pathways that contribute to comorbid symptoms across disorders. We highlight the current state of the art in our understanding of emotional dysregulation in SCZ versus MD by focusing on broad domains of behavioral function that can map onto underlying neural systems, namely deficits in hedonics, anticipatory behaviors, computations underlying value and effort, and effortful goal-directed behaviors needed to pursue rewarding outcomes. We highlight unique disturbances in each disorder that may involve dissociable neural systems, but also possible interactions between affect and cognition in MD versus SCZ. Finally, we review computational and translational approaches that offer mechanistic insight into how cellular-level disruptions can lead to complex affective disturbances, informing development of therapies across MD and SCZ.
Indexed as
Identifiers
26869843PMC4734880What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.