Evidence map›Paper›PMID 26869779›Full record

ArticleClinical interventions in aging2016

An exploratory intervention study suggests clinical benefits of training in chronic stroke to be paralleled by changes in brain activity using repeated fMRI.

Barbara Landsmann, Daniela Pinter, Eva Pirker, Gerald Pichler, Walter Schippinger, Elisabeth M Weiss, Gabriel Mathie, Thomas Gattringer, Franz Fazekas, Christian Enzinger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review.International journal of environmental research and public health · 2022
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  12. Role of Rehabilitation in Neural Plasticity.Open access Macedonian journal of medical sciences · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Barbara LandsmannInstitute of Psychology, University of Graz, Graz, Austria; Department of Neurology, Medical University of Graz, Graz, Austria.
Daniela PinterDepartment of Neurology, Medical University of Graz, Graz, Austria.
Eva PirkerInstitute of Psychology, University of Graz, Graz, Austria; Department of Neurology, Medical University of Graz, Graz, Austria.
Gerald PichlerAlbert Schweitzer Clinic Graz, Graz, Austria.
Walter SchippingerAlbert Schweitzer Clinic Graz, Graz, Austria.
Elisabeth M WeissInstitute of Psychology, University of Graz, Graz, Austria.
Gabriel MathieDepartment of Neurology, Medical University of Graz, Graz, Austria.
Thomas GattringerDepartment of Neurology, Medical University of Graz, Graz, Austria.
Franz FazekasDepartment of Neurology, Medical University of Graz, Graz, Austria.
Christian EnzingerDepartment of Neurology, Medical University of Graz, Graz, Austria; Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria.
Medical University of Graz · ATAlbert Schweitzer Klinik · ATUniversity of Graz · ATHeliophysics · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies demonstrated changes in sensorimotor network activation over time after stroke that have been interpreted as partly compensatory. Locomotor and balance trainings may improve both mobility and cognition even in chronic stroke and thereby impact on cerebral activation patterns. We here aimed at testing these assumptions in an exploratory study to inform subsequent larger intervention studies. PATIENTS AND

methodsEight patients (73.3±4.4 years) with a chronic lacunar stroke (mean interval 3.7 years after the acute event with a range from 2 to 4 years) and residual leg paresis leading to gait disturbance received a guided 5-week training focusing on mobility, endurance, and coordination. Before and afterward, they underwent clinical, neuropsychological, and gait assessments and brain MRI at 3 T including a functional ankle movement paradigm. Sixteen healthy controls (HCs; 68.8±5.4 years) followed the same protocol without intervention.

resultsAfter training, patients had improved in mobility, memory, and delayed recall of memory. While cerebral activations in HC remained completely unaltered, patients showed increased activations in the right precentral gyrus, the right and left superior frontal gyri, and the right frontal lobe, with bipedal ankle movements after training.

conclusionIn this exploratory study of chronic stroke, we found not only significant effects of physical training on mobility but also distinct aspects of cognition already with a small number of highly selected patients. These improvements were paralleled by alterations in cerebral activity possibly reflecting neuronal plasticity. Larger studies including randomization are needed.

Indexed as

GaitMagnetic Resonance ImagingStroke RehabilitationAgedAged, 80 and overCase-Control StudiesChronic DiseaseCognitionExercise TherapyFemaleFrontal LobeFunctional LateralityHumansMaleMemoryMovementcognitionlacunar strokemobilityneuronal plasticityrehabilitationtraining

Identifiers

PMID26869779
PMCPMC4734728
OpenAlexW2281393984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.