ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Tryptophan hydroxylase 2 deficiency alters autism-related behavioural phenotypes in rats.Scientific reports · 2025Article
- Central Serotonin Deficiency Impairs Recovery of Sensorimotor Abilities After Spinal Cord Injury in Rats.International journal of molecular sciences · 2025Article
- Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits.Molecular autism · 2024Article
- Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats.Frontiers in psychiatry · 2024Article
- Constitutive depletion of brain serotonin differentially affects rats' social and cognitive abilities.iScience · 2023Article
- Transformation of Our Understanding of Breathing Control by Molecular Tools.Annual review of physiology · 2023Review
- A serotonin-deficient rat model of neurogenic hypertension: influence of sex and sympathetic vascular tone.Journal of neurophysiology · 2022Article
- Tryptophan Hydroxylase 2 Knockout Male Rats Exhibit a Strengthened Oxytocin System, Are Aggressive, and Are Less Anxious.ACS chemical neuroscience · 2022Article
- Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons.Frontiers in synaptic neuroscience · 2022Article
- Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex.Physiological reports · 2021Article
- Phenylalanine hydroxylase contributes to serotonin synthesis in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Sex- and age-based differences in the effect of central serotonin on arterial blood pressure regulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Take a deep breath and wake up: The protean role of serotonin preventing sudden death in infancy.Experimental neurology · 2020Review
- The Absence of Serotonin in the Brain Alters Acute Stress Responsiveness by Interfering With the Genomic Function of the Glucocorticoid Receptors.Frontiers in cellular neuroscience · 2020Article
- The serotonergic system and the control of breathing during development.Respiratory physiology & neurobiology · 2019Review
- Increased central cholinergic drive contributes to the apneas of serotonin-deficient rat pups during active sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Acute and chronic changes in the control of breathing in a rat model of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Central serotonin and the control of arterial blood pressure and heart rate in infant rats: influence of sleep state and sex.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
Genetic deletion of brain serotonin (5-HT) neurons in mice leads to ventilatory deficits and increased neonatal mortality during development. However, it is unclear if the loss of the 5-HT neurons or the loss of the neurochemical 5-HT led to the observed physiologic deficits. Herein, we generated a mutant rat model with constitutive central nervous system (CNS) 5-HT depletion by mutation of the tryptophan hydroxylase 2 (Tph2) gene in dark agouti (DA(Tph2-/-)) rats. DA(Tph2-/-) rats lacked TPH immunoreactivity and brain 5-HT but retain dopa decarboxylase-expressing raphe neurons. Mutant rats were also smaller, had relatively high mortality (∼50%), and compared with controls had reduced room air ventilation and body temperatures at specific postnatal ages. In adult rats, breathing at rest and hypoxic and hypercapnic chemoreflexes were unaltered in adult male and female DA(Tph2-/-) rats. Body temperature was also maintained in adult DA(Tph2-/-) rats exposed to 4°C, indicating unaltered ventilatory and/or thermoregulatory control mechanisms. Finally, DA(Tph2-/-) rats treated with the 5-HT precursor 5-hydroxytryptophan (5-HTP) partially restored CNS 5-HT and showed increased ventilation (P < 0.05) at a developmental age when it was otherwise attenuated in the mutants. We conclude that constitutive CNS production of 5-HT is critically important to fundamental homeostatic control systems for breathing and temperature during postnatal development in the rat.
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