ReviewThe Plant cell2016
Small Genetic Circuits and MicroRNAs: Big Players in Polymerase II Transcriptional Control in Plants.
Review in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Intermittent light enhances pigment production in the diatomMicrobiology spectrum · 2026Article
- MicroRNA-Mediated Hormonal Control of Fruit Morphology.Plants (Basel, Switzerland) · 2026Review
- Determination of Expression Patterns of Plant miRNAs by Transcriptional Fusion Using GUS and Fluorescent Reporters.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- Transcriptional Regulation of zma-International journal of molecular sciences · 2022Article
- Differential Response of Grapevine to Infection with 'International journal of molecular sciences · 2021Article
- Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network.Frontiers in plant science · 2021Article
- Dynamic architecture and regulatory implications of the miRNA network underlying the response to stress in melon.RNA biology · 2020Article
- MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway.Molecular and cellular biology · 2019Article
- A revolutionary tool: CRISPR technology plays an important role in construction of intelligentized gene circuits.Cell proliferation · 2019Review
- Inferring the regulatory network of the miRNA-mediated response to biotic and abiotic stress in melon.BMC plant biology · 2019Article
- A Small RNA-Mediated Regulatory Network inFrontiers in plant science · 2019Article
- Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant.Nucleic acids research · 2018Article
- Biogenesis and regulatory hierarchy of phased small interfering RNAs in plants.Plant biotechnology journal · 2018Review
- The legume miR1514a modulates a NAC transcription factor transcript to trigger phasiRNA formation in response to drought.Journal of experimental botany · 2017Article
- Systems biology study of transcriptional and post-transcriptional co-regulatory network sheds light on key regulators involved in important biological processes inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2017Article
- The Plant Cell Reviews Small RNA and Chromatin Dynamics: From Small Genetic Circuits to Complex Genomes.The Plant cell · 2016Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
RNA Polymerase II (Pol II) regulatory cascades involving transcription factors (TFs) and their targets orchestrate the genetic circuitry of every eukaryotic organism. In order to understand how these cascades function, they can be dissected into small genetic networks, each containing just a few Pol II transcribed genes, that generate specific signal-processing outcomes. Small RNA regulatory circuits involve direct regulation of a small RNA by a TF and/or direct regulation of a TF by a small RNA and have been shown to play unique roles in many organisms. Here, we will focus on small RNA regulatory circuits containing Pol II transcribed microRNAs (miRNAs). While the role of miRNA-containing regulatory circuits as modular building blocks for the function of complex networks has long been on the forefront of studies in the animal kingdom, plant studies are poised to take a lead role in this area because of their advantages in probing transcriptional and posttranscriptional control of Pol II genes. The relative simplicity of tissue- and cell-type organization, miRNA targeting, and genomic structure make the Arabidopsis thaliana plant model uniquely amenable for small RNA regulatory circuit studies in a multicellular organism. In this Review, we cover analysis, tools, and validation methods for probing the component interactions in miRNA-containing regulatory circuits. We then review the important roles that plant miRNAs are playing in these circuits and summarize methods for the identification of small genetic circuits that strongly influence plant function. We conclude by noting areas of opportunity where new plant studies are imminently needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.