Evidence map›Paper›PMID 26869680›Full record

Trial reportPhysiological reports2016

A 3-week multimodal intervention involving high-intensity interval training in female cancer survivors: a randomized controlled trial.

Joachim Schmitt, Nathalie Lindner, Monika Reuss-Borst, Hans-Christer Holmberg, Billy Sperlich

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04679233 (Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy), which is not on this map. Cited by 48 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04679233 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy

TypeinterventionalSponsorVanderbilt UniversityRan2021 to 2021Enrolled0ConditionsHead and Neck Neoplasm, RadiotherapyArmsPrescription aerobic exercise
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Efficacy of different non-pharmacological therapies on cancer-related fatigue in breast cancer patients: a network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  4. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  5. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
    Pooled it
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  9. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
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  11. Short-Term (<8 wk) High-Intensity Interval Training in Diseased Cohorts.Medicine and science in sports and exercise · 2018
    Pooled it
  12. Barriers and facilitators of exercise experienced by cancer survivors: a mixed methods systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  13. Safety and feasibility of exercise interventions in patients with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joachim SchmittRehaklinik am Kurpark, RehaZentren Baden Württemberg gGmbH, Bad Kissingen, Germany.
Nathalie LindnerIntegrative and Experimental Training Science, Department of Sport Science, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Monika Reuss-BorstRehaklinik am Kurpark, RehaZentren Baden Württemberg gGmbH, Bad Kissingen, Germany.
Hans-Christer HolmbergSwedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
Billy SperlichIntegrative and Experimental Training Science, Department of Sport Science, Julius-Maximilians-Universität Würzburg, Würzburg, Germany billy.sperlich@uni-wuerzburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To compare the effects of a 3-week multimodal rehabilitation involving supervised high-intensity interval training (HIIT) on female breast cancer survivors with respect to key variables of aerobic fitness, body composition, energy expenditure, cancer-related fatigue, and quality of life to those of a standard multimodal rehabilitation program. A randomized controlled trial design was administered. Twenty-eight women, who had been treated for cancer were randomly assigned to either a group performing exercise of low-to-moderate intensity (LMIE; n = 14) or a group performing high-intensity interval training (HIIT; n = 14) as part of a 3-week multimodal rehabilitation program. No adverse events related to the exercise were reported. Work economy improved following both HIIT and LMIE, with improved peak oxygen uptake following LMIE. HIIT reduced mean total body fat mass with no change in body mass, muscle or fat-free mass (best P < 0.06). LMIE increased muscle and total fat-free body mass. Total energy expenditure (P = 0.45) did not change between the groups, whereas both improved quality of life to a similar high extent and lessened cancer-related fatigue. This randomized controlled study demonstrates that HIIT can be performed by female cancer survivors without adverse health effects. Here, HIIT and LMIE both improved work economy, quality of life and cancer-related fatigue, body composition or energy expenditure. Since the outcomes were similar, but HIIT takes less time, this may be a time-efficient strategy for improving certain aspects of the health of female cancer survivors.

Indexed as

Quality of LifeAdultBreast NeoplasmsExercise TherapyFatigueFemaleHumansMiddle AgedSurvivorsCancer survivorscardiorespiratory fitnessenergy expenditureexerciserehabilitationsense wear

Identifiers

PMID26869680
PMCPMC4758922

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.