ArticleThe American journal of cardiology2016
Carotid Plaque Characterization, Stenosis, and Intima-Media Thickness According to Age and Gender in a Large Registry Cohort.
Article in The American journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The association of CHA2DS2-VASc score and carotid plaque in patients with non-valvular atrial fibrillation.PloS one · 2019Trial
- Leukocyte Count Is Better than LDL-C as Predictor of Novel Carotid Atherosclerosis.Biomedicines · 2025Article
- The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Using Machine Learning to Predict Abnormal Carotid Intima-Media Thickness in Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2023Article
- Homocysteine Combined with Apolipoprotein B as Serum Biomarkers for Predicting Carotid Atherosclerosis in the Oldest-Old.Clinical interventions in aging · 2023Article
- Influence of shift work on cardiovascular disease risk in Southern African long-distance truck drivers: a cross-sectional study.BMJ open · 2022Article
- Effects of adult growth hormone deficiency and replacement therapy on the cardiometabolic risk profile.Pituitary · 2022Review
- Multimodality carotid plaque tissue characterization and classification in the artificial intelligence paradigm: a narrative review for stroke application.Annals of translational medicine · 2021Review
- Impact of Age and Sex on Subclinical Coronary Atherosclerosis in a Healthy Asian Population.JACC. Asia · 2021Article
- Low Skeletal Muscle Mass Is a Risk Factor for Subclinical Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease.Diagnostics (Basel, Switzerland) · 2021Article
- Association of Carotid Intima-Media Thickness and Other Carotid Ultrasound Features With Incident Dementia in the ARIC-NCS.Journal of the American Heart Association · 2021Article
- Article
- Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study.Scientific reports · 2021Observational
- Cardiovascular disease risk and its determinants in people living with HIV across different settings in South Africa.HIV medicine · 2020Article
- Cardiovascular Disease Burden in Rural Africa: Does HIV and Antiretroviral Treatment Play a Role?: Baseline Analysis of the Ndlovu Cohort Study.Journal of the American Heart Association · 2020Article
- Cardiovascular risk assessment: The foundation of preventive cardiology.American journal of preventive cardiology · 2020Review
- Cardiovascular disease risk in an urban African population: a cross-sectional analysis on the role of HIV and antiretroviral treatment.Retrovirology · 2019Article
- The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes.International journal of molecular sciences · 2019Review
- Article
- Associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing maintenance hemodialysis.BMC nephrology · 2018Article
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5 authors.
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Abstract
Carotid intima-media thickness (CIMT) is a well-established predictor of cardiovascular disease events. Not well described, however, is the prevalence of plaque and stenosis severity and how this varies according to extent of CIMT, age, and gender. We evaluated the extent of carotid plaque and stenosis severity according to CIMT, age, and gender in a large CIMT screening registry. We studied 9,347 women and 12,676 men (n = 22,023) who received carotid ultrasound scans. The presence and severity of both carotid plaque and stenosis was compared according to extent of CIMT (≥1 mm vs <1 mm), age, and gender using the chi-square test of proportions. Among those aged <45 to ≥80 years, the prevalence of CIMT ≥1 mm ranged from 0.13% to 29.3% in women and 0.6% to 40.1% in men, stenosis ≥50% from 0.1% to 14.9% in women and 0.1% to 13.2% in men, and mixed and/or soft plaque from 7.1% to 66.5% in women, and 9.2% to 65.8% in men (all p <0.001 across age groups). Even when CIMT levels were <1 mm, >30% of patients demonstrated mixed or soft plaque potentially prone to rupture. Of those with CIMT ≥1 mm, more than 70% had such mixed or soft plaque and more than 40% demonstrated stenoses of 30% or greater. In conclusion, we describe in a large CIMT registry study a substantial age-related increase in both men and women of increased CIMT, plaque presence, and severity, and stenosis. Even in those with normal CIMT, mixed or soft plaque was common, further demonstrating the value in assessing for plaque when doing carotid ultrasound.
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