ArticleBMC public health2016
Maternal urinary manganese and risk of low birth weight: a case-control study.
Article in BMC public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Assessing the multi-dimensional effects of air pollution on maternal complications and birth outcomes: A structural equation modeling approach.Hygiene and environmental health advances · 2024Article
- Associations of intrauterine exposure to manganese with fetal and early-childhood growth: a prospective prenatal cohort study.Environmental science and pollution research international · 2024Article
- Article
- Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil.International journal of environmental research and public health · 2023Article
- Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort.Environmental health perspectives · 2023Article
- Pregnancy Outcome in Women Exposed to Metal Fume in Welding: A Canadian Cohort Study.Annals of work exposures and health · 2022Article
- Prenatal metal mixture exposure and birth weight: A two-stage analysis in two prospective cohort studies.Eco-Environment & Health · 2022Article
- Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES.Exposure and health · 2021Article
- Maternal risk factors for low birth weight infants: A nested case-control study of rural areas in Kurdistan (western of Iran).Journal of preventive medicine and hygiene · 2021Article
- Prenatal exposure to multiple metals and birth outcomes: An observational study within the National Children's Study cohort.Environment international · 2021Observational
- Exposure to uranium and co-occurring metals among pregnant Navajo women.Environmental research · 2020Article
- Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Environmental & occupational exposure & female reproductive dysfunction.The Indian journal of medical research · 2019Review
- Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Urinary concentrations of environmental metals and associating factors in pregnant women.Environmental science and pollution research international · 2019Article
- In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort.Environmental research · 2019Article
- Assessment of heavy metals (total chromium, lead, and manganese) contamination of residential soil and homegrown vegetables near a former chemical manufacturing facility in Tarnaveni, Romania.Environmental monitoring and assessment · 2018Article
- Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China.Environmental health perspectives · 2018Article
- Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network.Environment international · 2018Article
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundManganese (Mn) is an essential element for humans, but exposure to high levels has been associated with adverse developmental outcomes. Early epidemiological studies evaluating the effect of Mn on fetal growth are inconsistent.
methodsWe investigated the association between maternal urinary Mn during pregnancy and the risk of low birth weight (LBW). Mn concentrations in maternal urine samples collected before delivery were measured in 816 subjects (204 LBW cases and 612 matched controls) recruited between 2012 and 2014 in Hubei Province, China.
resultsThe median Mn concentration in maternal urine was 0.69 μg/g creatinine. Compared to the medium tertile of Mn levels, an increased risk of LBW was observed for the lowest tertile (≤0.30 μg/g creatinine) [adjusted odds ratio (OR) = 1.28; 95 % confidence interval (CI) = 0.67, 2.45], and a significantly increased risk of LBW was observed for the highest tertile (≥1.16 μg/g creatinine) [adjusted OR = 2.04; 95 % CI = 1.12, 3.72]. A curvilinear relationship between maternal urinary Mn and risk of LBW was observed, showing that the concentration at 0.43 μg/g creatinine was the point of inflection. Similar associations were observed among the mothers with female infants and among the younger mothers < 28 years old. However, among the mothers with male infants or the older mothers ≥ 28 years old, only higher levels of Mn were positively associated with LBW.
conclusionsLower or higher levels of maternal urinary Mn are associated with LBW, though only the association of LBW risk and higher levels of Mn was statistically significant. The findings also show that the associations may vary by maternal age and infant sex, but require confirmation in other populations.
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