ReviewVeterinary pathology2016
Contributions of Nonhuman Primates to Research on Aging.
Review in Veterinary pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 84 citations in OpenAlex.
- A Comparative Study of Plasma Biomarkers of Neurodegeneration in Rhesus Monkeys (bioRxiv : the preprint server for biology · 2026Article
- A Comparative Study of Aging and Cortical Folding in Chimpanzees and Olive Baboons.American journal of primatology · 2026Article
- SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques.Journal of leukocyte biology · 2026Article
- Menstrual cycles, lifespan, and anti-Müllerian hormone in cynomolgus monkeys.Experimental animals · 2026Article
- Effects of Lifelong Low Social Status on Inflammatory Markers in Adult Female Macaques.Biomolecules · 2026Article
- Neutrophil kinetics ofFrontiers in cellular and infection microbiology · 2026Article
- Article
- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Combination antiretroviral therapy prevents SIV-induced aging in the hippocampus and neurodegeneration throughout the brain.Journal of neurovirology · 2025Article
- Understanding Tau pathology: Insights from animal models.Zoological research · 2025Review
- A Survey of the Reproductive Lesions in Captive Female Non-Human Primates in Italy.Veterinary sciences · 2025Article
- Article
- Spontaneous mammalian models for Alzheimer's disease and dementia.Brain communications · 2025Review
- Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates.Heliyon · 2024Article
- Behavioral Training in First-Generation Long-Tailed Macaques (Animals : an open access journal from MDPI · 2024Article
- Bearded capuchin monkeys as a model for Alzheimer's disease.Scientific reports · 2024Article
- Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.Nature aging · 2024Article
- Astrocyte expression of aging-associated markers positively correlates with neurodegeneration in the frontal lobe of the rhesus macaque brain.Frontiers in aging neuroscience · 2024Article
- Bearded capuchin monkey as a model for Alzheimer's disease research.Research square · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Aging is the biological process of declining physiologic function associated with increasing mortality rate during advancing age. Humans and higher nonhuman primates exhibit unusually longer average life spans as compared with mammals of similar body mass. Furthermore, the population of humans worldwide is growing older as a result of improvements in public health, social services, and health care systems. Comparative studies among a wide range of organisms that include nonhuman primates contribute greatly to our understanding about the basic mechanisms of aging. Based on their genetic and physiologic relatedness to humans, nonhuman primates are especially important for better understanding processes of aging unique to primates, as well as for testing intervention strategies to improve healthy aging and to treat diseases and disabilities in older people. Rhesus and cynomolgus macaques are the predominant monkeys used in studies on aging, but research with lower nonhuman primate species is increasing. One of the priority topics of research about aging in nonhuman primates involves neurologic changes associated with cognitive decline and neurodegenerative diseases. Additional areas of research include osteoporosis, reproductive decline, caloric restriction, and their mimetics, as well as immune senescence and chronic inflammation that affect vaccine efficacy and resistance to infections and cancer. The purpose of this review is to highlight the findings from nonhuman primate research that contribute to our understanding about aging and health span in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.