ArticleScientific reports2016
Genetic diversity at the Dhn3 locus in Turkish Hordeum spontaneum populations with comparative structural analyses.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Integrated multi-omics analysis reveals drought stress response mechanism in chickpea (Cicer arietinum L.).The plant genome · 2024Article
- Identification, Characterization, and Expression Profile Analysis of theFrontiers in plant science · 2021Article
- Genetic variation of HvXYN1 associated with endoxylanase activity and TAX content in barley (Hordeum vulgare L.).BMC plant biology · 2019Article
- Continuous Automated Model EvaluatiOn (CAMEO) complementing the critical assessment of structure prediction in CASP12.Proteins · 2018Article
- Genetic variations of HvP5CS1 and their association with drought tolerance related traits in barley (Hordeum vulgare L.).Scientific reports · 2017Article
- Barley Genes as Tools to Confer Abiotic Stress Tolerance in Crops.Frontiers in plant science · 2016Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
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Abstract
We analysed Hordeum spontaneum accessions from 21 different locations to understand the genetic diversity of HsDhn3 alleles and effects of single base mutations on the intrinsically disordered structure of the resulting polypeptide (HsDHN3). HsDHN3 was found to be YSK2-type with a low-frequency 6-aa deletion in the beginning of Exon 1. There is relatively high diversity in the intron region of HsDhn3 compared to the two exon regions. We have found subtle differences in K segments led to changes in amino acids chemical properties. Predictions for protein interaction profiles suggest the presence of a protein-binding site in HsDHN3 that coincides with the K1 segment. Comparison of DHN3 to closely related cereals showed that all of them contain a nuclear localization signal sequence flanking to the K1 segment and a novel conserved region located between the S and K1 segments [E(D/T)DGMGGR]. We found that H. vulgare, H. spontaneum, and Triticum urartu DHN3s have a greater number of phosphorylation sites for protein kinase C than other cereal species, which may be related to stress adaptation. Our results show that the nature and extent of mutations in the conserved segments of K1 and K2 are likely to be key factors in protection of cells.
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