ArticleNeuroscience2017
Midline thalamic reuniens lesions improve executive behaviors.
Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Paired associates learning performance in rats requires the nucleus reuniens.Behavioral neuroscience · 2026Article
- Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration.Neuropharmacology · 2026Article
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- The reuniens thalamus recruits recurrent excitation in the medial prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Medial prefrontal cortex to nucleus reuniens circuit is critical for performance in an operant delayed nonmatch to position task.Neurobiology of learning and memory · 2025Article
- Long-Term Outcomes and Survival Rates of Patients Undergoing Biopsy Vs. Maximum Safe Resection for Thalamic Lesions: A Short Review on Current Evidence.Galen medical journal · 2024Review
- The anterior thalamic nuclei and nucleus reuniens: So similar but so different.Neuroscience and biobehavioral reviews · 2020Review
- The Cognitive Thalamus as a Gateway to Mental Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Prefrontal cortex modulates firing pattern in the nucleus reuniens of the midline thalamus via distinct corticothalamic pathways.The European journal of neuroscience · 2018Article
- Anterior thalamic nuclei, but not retrosplenial cortex, lesions abolish latent inhibition in rats.Behavioral neuroscience · 2018Article
- Ventral Midline Thalamus Is Necessary for Hippocampal Place Field Stability and Cell Firing Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Lesions of the ventral midline thalamus produce deficits in reversal learning and attention on an odor texture set shifting task.Brain research · 2016Article
- Modulation of sensitivity to alcohol by cortical and thalamic brain regions.The European journal of neuroscience · 2016Article
- The Nucleus Reuniens of the Midline Thalamus Gates Prefrontal-Hippocampal Modulation of Ventral Tegmental Area Dopamine Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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3 authors.
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Abstract
The role of the thalamus in complex cognitive behavior is a topic of increasing interest. Here we demonstrate that lesions of the nucleus reuniens (NRe), a midline thalamic nucleus interconnected with both hippocampal and prefrontal circuitry, lead to enhancement of executive behaviors typically associated with the prefrontal cortex. Rats were tested on four behavioral tasks: (1) the combined attention-memory (CAM) task, which simultaneously assessed attention to a visual target and memory for that target over a variable delay; (2) spatial memory using a radial arm maze, (3) discrimination and reversal learning using a touchscreen operant platform, and (4) decision-making with delayed outcomes. Following NRe lesions, the animals became more efficient in their performance, responding with shorter reaction times but also less impulsively than controls. This change, combined with a decrease in perseverative responses, led to focused attention in the CAM task and accelerated learning in the visual discrimination task. There were no observed changes in tasks involving either spatial memory or value-based decision making. These data complement ongoing efforts to understand the role of midline thalamic structures in human cognition, including the development of thalamic stimulation as a therapeutic strategy for acquired cognitive disabilities (Schiff, 2008; Mair et al., 2011), and point to the NRe as a potential target for clinical intervention.
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