ArticleNature communications2016
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- In situ architecture of the intercellular organelle reservoir between epididymal epithelial cells by volume electron microscopy.Nature communications · 2025Article
- Molecular Pathways Implicated in the Differentiation and Function of Epididymal Basal Cells.Advances in experimental medicine and biology · 2025Review
- Basal and Immune Cells of the Epididymis: An Electron Microscopy View of Their Association.Advances in experimental medicine and biology · 2025Review
- In vivo dynamic volumetric imaging of mouse testis and epididymis with optical coherence tomography†.Biology of reproduction · 2024Article
- The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis†.Biology of reproduction · 2022Article
- Sperm acquire epididymis-derived proteins through epididymosomes.Human reproduction (Oxford, England) · 2022Article
- Vacuolar H(+)-ATPase is not restricted to clear cells of the epididymal epithelium in cattle.Journal of animal science and technology · 2021Article
- Development and Differentiation of Epididymal Epithelial Cells in Korean Native Black Goat.Animals : an open access journal from MDPI · 2020Article
- Distribution pattern of ZO-1 and claudins in the epididymis of vampire bats.Tissue barriers · 2020Article
- Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity.Journal of cell science · 2019Article
- Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa.Andrology · 2019Review
- Unravelling purinergic regulation in the epididymis: activation of V-ATPase-dependent acidification by luminal ATP and adenosine.The Journal of physiology · 2019Article
- Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4.Scientific reports · 2018Article
- Identification, characterization and purification of porcine Quiescin Q6-Sulfydryl Oxidase 2 protein.BMC veterinary research · 2017Article
- The expression patterns of aquaporin 9, vacuolar HHistochemistry and cell biology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections--which we call axiopodia--periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.