ArticleGenetics2016
A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus).
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Recombination suppression in plant adaptation and speciation.The New phytologist · 2026Review
- Article
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- Evolution of Large Polymorphic Inversions in a Panmictic Songbird.Molecular biology and evolution · 2025Article
- Limited population structure but signals of recent selection in introduced African Fig Fly (Zaprionus indianus) in North America.G3 (Bethesda, Md.) · 2025Article
- Effects of inbreeding on balancing selection: insights from Fisher's geometric model.Genetics · 2025Article
- Among- and within-population variation in germination response shapes ecological resilience in the Mediterranean cliff species Brassica incana.Annals of botany · 2025Article
- Bridging micro and macroevolution: insights from chromosomal dynamics in plants.Frontiers in plant science · 2025Review
- Article
- The Influence of Chromosomal Inversions on Genetic Variation and Clinal Patterns in Genomic Data of Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Testing the evolutionary theory of inversion polymorphisms in the yellow monkeyflower (Mimulus guttatus).Nature communications · 2024Article
- The quantitative genetics of gene expression in Mimulus guttatus.PLoS genetics · 2024Article
- Postzygotic barriers persist despite ongoing introgression in hybridizing Mimulus species.Molecular ecology · 2024Article
- The genomic scale of fluctuating selection in a natural plant population.Evolution letters · 2022Article
- Three problems in the genetics of speciation by selection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Identification and validation of QTLs for tuber quality related traits in greater yam (Dioscorea alata L.).Scientific reports · 2022Article
- Population differentiation and structural variation in the Manduca sexta genome across the United States.G3 (Bethesda, Md.) · 2022Article
- A supergene underlies linked variation in color and morphology in a Holarctic songbird.Nature communications · 2021Article
- Genetic variation for adaptive traits is associated with polymorphic inversions inEvolution letters · 2021Article
- Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers.PLoS genetics · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Polymorphic chromosomal rearrangements can bind hundreds of genes into single genetic loci with diverse effects. Rearrangements are often associated with local adaptation and speciation and may also be an important component of genetic variation within populations. We genetically and phenotypically characterize a segregating inversion (inv6) in the Iron Mountain (IM) population of Mimulus guttatus (yellow monkeyflower). We initially mapped inv6 as a region of recombination suppression in three F2 populations resulting from crosses among IM plants. In each case, the F1 parent was heterozygous for a derived haplotype, homogenous across markers spanning over 5 Mb of chromsome 6. In the three F2 populations, inv6 reduced male and female fitness components. In addition,i nv6 carriers suffered an ∼30% loss of pollen viability in the field. Despite these costs, inv6 exists at moderate frequency (∼8%) in the natural population, suggesting counterbalancing fitness benefits that maintain the polymorphism. Across 4 years of monitoring in the field, inv6 had an overall significant positive effect on seed production (lifetime female fitness) of carriers. This benefit was particularly strong in harsh years and may be mediated (in part) by strong positive effects on flower production. These data suggest that opposing fitness effects maintain an intermediate frequency, and as a consequence, inv6 generates inbreeding depression and high genetic variance. We discuss these findings in relation to the theory of inbreeding depression and the maintenance of fitness variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.