Evidence map›Paper›PMID 26868636›Full record

ArticleBMC research notes2016

Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation.

Fiona Moghaddas, Fredrick Joshua, Roberta Taylor, Marvin J Fritzler, Ban Hock Toh

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Fiona MoghaddasAustralian Clinical Laboratories, Melbourne, Australia. moghaddas.f@wehi.edu.au.
Fredrick JoshuaDepartment of Rheumatology, Prince of Wales Hospital, Sydney, Australia. fredjoshua@unsw.edu.au.
Roberta TaylorAustralian Clinical Laboratories, Melbourne, Australia. Roberta.Taylor@clinicallabs.com.au.
Marvin J FritzlerDepartment of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. fritzler@ucalgary.ca.
Ban Hock TohAustralian Clinical Laboratories, Melbourne, Australia. ban-hock.toh@monash.edu.
Monash University · AUPrince of Wales Hospital · AUUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutoantibodies directed to centromere protein F were first reported in 1993 and their association with malignancy has been well documented. CASE: We present the case of a 48-year-old Caucasian female with a BRCA1 gene mutation associated with bilateral breast cancer. Antinuclear autoantibody immunofluorescence performed for workup of possible inflammatory arthropathy showed a high titre cell cycle related nuclear speckled pattern, with subsequent confirmation by addressable laser bead immunoassay of the target antigen as an immunodominant epitope at the C-terminus of centromere protein F.

conclusionHere we review the current literature on centromere protein F, its association with breast cancer and present the first case of this antibody being identified in a person with a BRCA1 gene mutation.

Indexed as

Genes, BRCA1AutoantibodiesCell CycleChromosomal Proteins, Non-HistoneFemaleHumansMicrofilament ProteinsMiddle AgedMutationAutoantibodiescentromere protein FChromosomal Proteins, Non-HistoneMicrofilament Proteins

Identifiers

PMID26868636
PMCPMC4750191
OpenAlexW2258803642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.