Trial reportHematology (Amsterdam, Netherlands)2016
Complications of sickle cell anaemia in children in Northwestern Tanzania.
Trial report in Hematology (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Neurologic complications of sickle cell disease in Africa: A systematic review and meta-analysis.Neurology · 2017Pooled it
- Persistent Splenomegaly Is Associated with Morbidity in Tanzanian Children with Sickle Cell Anemia: Secondary Analysis of the SPHERE Trial.Acta haematologica · 2026Article
- Creative and Adaptive Solutions for Early Diagnosis of Sickle Cell Disease in Sub-Saharan Africa.American journal of hematology · 2026Review
- Clinical presentation and outcomes of children hospitalized with sickle cell anemia at Gulu regional referral hospital, Uganda: a retrospective cross-sectional study.Scientific reports · 2025Article
- Epidemiological and clinical profile of sickle cell disease in a series of Moroccan children.Journal of community genetics · 2025Article
- Early-life clinical and hematological profiles: a comparative study of children with and without sickle cell disease in the first three years of life.Annals of hematology · 2025Article
- Prevention of stroke and cognitive decline in pediatric population in resource-limited settings.Frontiers in stroke · 2024Review
- Outcomes of Hydroxyurea Accessed via Various Means and Barriers Affecting Its Usage Among Children with Sickle Cell Anaemia in North-Western Tanzania.Journal of blood medicine · 2023Article
- Review
- Health Related Quality of Life among Children with Sickle Cell Anaemia in Northwestern Tanzania.Open journal of blood diseases · 2022Article
- Developing a Sustainable Cardiovascular Disease Research Strategy in Tanzania Through Training: Leveraging From the East African Centre of Excellence in Cardiovascular Sciences Project.Frontiers in cardiovascular medicine · 2022Review
- Epidemiology of Stroke in Sickle Cell Disease.Journal of clinical medicine · 2021Review
- Article
- Article
- Improvement of SCD morbimortality in children: experience in a remote area of an African country.BMC health services research · 2021Article
- Perspectives on Building Sustainable Newborn Screening Programs for Sickle Cell Disease: Experience from Tanzania.International journal of neonatal screening · 2021Article
- Addressing unmet basic needs for children with sickle cell disease in the United States: clinic and staff perspectives.BMC health services research · 2021Article
- Paediatric sickle cell disease at a tertiary hospital in Malawi: a retrospective cross-sectional study.BMJ paediatrics open · 2021Article
- Influence of gender norms in relation to child's quality of care: follow-up of families of children with SCD identified through NBS in Tanzania.Journal of community genetics · 2021Article
- Blood Transfusion Frequency and Indications in Yemeni Children with Sickle Cell Disease.Anemia · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesTanzania has the third highest birth rate of sickle cell anaemia (SCA) in Africa, but few studies describe severity of complications or available treatments, especially in Northwest Tanzania around Lake Victoria where the sickle gene is most prevalent. This is a report of the spectrum of clinical disease and range of interventions available at Bugando Medical Centre (Bugando) in Northwest Tanzania in Africa.
methodsA cross-sectional study was carried out in Bugando between 1 August 2012 and 30 September 2012. Children (<15 years old) with SCA attending Bugando were sequentially enrolled. A trained research assistant completed a Swahili questionnaire with the parent or guardian of each participant concerning demographic information, clinical features of disease, and treatments received.
resultsAmong the 124 participants enrolled, the median age was 6 years (interquartile range [IQR] 4-8.5), and only 13 (10.5%) were < 3 years old. Almost all participants (97.6%) had a prior history of a vaso-occlusive episode, 83 (66.9%) had prior acute chest syndrome, and 21 (16.9%) had prior stroke. In the preceding 12 months, 120 (96.8%) had been hospitalized, and a vaso-occlusive episode was the most common reason for hospitalization (35.5%). Prescriptions for folic acid (92.7%) and malaria prophylaxis (84.7%) were common, but only one had received a pneumococcal vaccine, and none had received hydroxyurea or prophylactic penicillin.
conclusionChildren with SCA receiving care in Tanzania are diagnosed late, hospitalized frequently, and have severe complications. Opportunities exist to improve care through wider access to screening and diagnosis as well as better coordination of comprehensive care.
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Registered trials
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