ArticleScientific reports2016
Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Review
- Review
- Lifestyle modifications with anti-neuroinflammatory benefits in the aging population.Experimental gerontology · 2020Review
- Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms.Scientific reports · 2020Article
- Glial remodeling enhances short-term memory performance in Wistar rats.Journal of neuroinflammation · 2020Article
- Stress Response Simulated by Continuous Injection of ACTH Attenuates Lipopolysaccharide-Induced Inflammation in Porcine Adrenal Gland.Frontiers in veterinary science · 2020Article
- High Fat Programming and Cardiovascular Disease.Medicina (Kaunas, Lithuania) · 2018Review
- The initiation of metabolic inflammation in childhood obesity.The Journal of clinical investigation · 2017Review
- Hyperleptinemia in Neonatally Overfed Female Rats Does Not Dysregulate Feeding Circuitry.Frontiers in endocrinology · 2017Article
- Neonatal overfeeding disrupts pituitary ghrelin signalling in female rats long-term; Implications for the stress response.PloS one · 2017Article
- Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity.Seminars in immunopathology · 2016Review
- Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice.Scientific reports · 2016Article
- Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning.Journal of neuroinflammation · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life diet can critically program hypothalamic-pituitary-adrenal (HPA) axis function. We have previously shown rats that are overfed as neonates have exacerbated pro-inflammatory responses to immune challenge with lipopolysaccharide (LPS), in part by altering HPA axis responses, but how this occurs is unknown. Here we examined neonatal overfeeding-induced changes in gene expression in each step of the HPA axis. We saw no differences in glucocorticoid or mineralocorticoid receptor expression in key regions responsible for glucocorticoid negative feedback to the brain and no differences in expression of key HPA axis regulatory genes in the paraventricular nucleus of the hypothalamus or pituitary. On the other hand, expression of the adrenal melanocortin 2 receptor (MC2R) is elevated after LPS in control rats, but significantly less so in the neonatally overfed. The in vitro adrenal response to ACTH is also dampened in these rats, while the in vivo response to ACTH does not resolve as efficiently as it does in controls. These data suggest neonatal diet affects the efficiency of the adrenally-mediated response to LPS, potentially influencing how neonatally overfed rats combat bacterial infection.
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