ArticleScientific reports2016
Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Early life chronic stress-disrupted activity of the dorsal raphe nucleus selectively drives behavioral impairments.Communications biology · 2026Article
- Disruption ofiScience · 2026Article
- Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026Review
- Integrated single-cell atlases unveil the operation principles of whole-brain 5-HT neuronal subsystems.Science advances · 2025Article
- A High-Throughput Behavioral Assay for Screening Novel Anxiolytics in Larval Zebrafish.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The Serotonergic Dorsal Raphe Promotes Emergence from Propofol Anesthesia in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Computational modeling of light processing in the habenula and dorsal raphe based on laser ablation of functionally-defined cells.BMC neuroscience · 2024Article
- Serotonin Strengthens a Developing Glutamatergic Synapse through a PI3K-Dependent Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multiple faces of stress in the zebrafish (Frontiers in physiology · 2024Article
- A novel small molecule, AS1, reverses the negative hedonic valence of noxious stimuli.BMC biology · 2023Article
- Zebrafish, a biological model for pharmaceutical research for the management of anxiety.Molecular biology reports · 2023Review
- A circadian-dependent preference for light displayed by Xenopus tadpoles is modulated by serotonin.iScience · 2022Article
- The habenula clock influences response to a stressor.Neurobiology of stress · 2021Article
- Optimized protocol for conditioned place avoidance learning in juvenile zebrafish.STAR protocols · 2021Article
- Article
- An Innate Color Preference Displayed byFrontiers in behavioral neuroscience · 2020Article
- The swimming plus-maze test: a novel high-throughput model for assessment of anxiety-related behaviour in larval and juvenile zebrafish (Danio rerio).Scientific reports · 2018Article
- Heritable natural variation of an anxiety-like behavior in larval zebrafish.Journal of neurogenetics · 2017Article
- Performance on innate behaviour during early development as a function of stress level.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonergic neurons have been implicated in a broad range of processes, but the principles underlying their effects remain a puzzle. Here, we ask how these neurons influence the tendency of larval zebrafish to swim in the light and avoid regions of darkness. Pharmacological inhibition of serotonin synthesis reduces dark avoidance, indicating an involvement of this neuromodulator. Calcium imaging of tph2-expressing cells demonstrates that a rostral subset of dorsal raphe serotonergic neurons fire continuously while the animal is in darkness, but are inhibited in the light. Optogenetic manipulation of tph2 neurons by channelrhodopsin or halorhodopsin expression modifies preference, confirming a role for these neurons. In particular, these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.