ArticleBMC research notes2016
A simple respiratory severity score that may be used in evaluation of acute respiratory infection.
Article in BMC research notes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of instruments aimed at evaluating the severity of bronchiolitis.Paediatric respiratory reviews · 2018Pooled it
- Application of machine learning to predict bronchiolitis severity in children: a single-centre retrospective cohort study.European journal of pediatrics · 2026Article
- Parental Ability to Identify Severe Illnesses in Their Children.JAMA network open · 2026Article
- Mannose-binding lectin insufficiency is associated with airway Haemophilus colonization and a higher risk of post-RSV bronchiolitis recurrent wheezing.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Article
- Comprehensive Review of COVID-19: Epidemiology, Pathogenesis, Advancement in Diagnostic and Detection Techniques, and Post-Pandemic Treatment Strategies.International journal of molecular sciences · 2024Review
- Normal saline for children with bronchiolitis: study protocol for a randomised controlled non-inferiority trial.BMJ paediatrics open · 2024Article
- Characterisation of RSV infections in children without chronic diseases aged 0-36 months during the post-COVID-19 winter season 2022/2023.Frontiers in pediatrics · 2024Article
- RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Multi-head deep learning framework for pulmonary disease detection and severity scoring with modified progressive learning.Biomedical signal processing and control · 2023Article
- Risk Factors Associated with Severe RSV Infection in Infants: What Is the Role of Viral Co-Infections?Microbiology spectrum · 2023Article
- Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study.Lancet (London, England) · 2023Article
- Comparison of severity scales for acute bronchiolitis in real clinical practice.European journal of pediatrics · 2023Review
- Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome.Journal of virology · 2023Article
- Upper respiratory tract bacterial-immune interactions during respiratory syncytial virus infection in infancy.The Journal of allergy and clinical immunology · 2022Article
- A retrospective study examining the clinical significance of testing respiratory panels in children who presented to a tertiary hospital in 2019.Access microbiology · 2022Article
- Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes.Nature microbiology · 2021Article
- A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.Journal of virology · 2020Article
- Article
- Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy.The Journal of allergy and clinical immunology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAcute respiratory infections are ubiquitous and may have long-term implications on respiratory health. There are many scoring systems used to objectively measure severity of respiratory infections in clinical and research settings. A respiratory severity score derived exclusively from physical exam components (RSS-HR) was studied as an objective measure of disease severity and was compared to a previously described score that uses pulse oximetry as a component of its score (RSS-SO).
findingsA score was derived from 497 infants. The RSS-HR median score was higher in infants that were hospitalized (8.0) versus outpatient (4.0, p < 0.001), and those with lower respiratory tract infections (LRTI) (6.5) versus upper respiratory infections (URI) (1.0, p < 0.001). When discriminating upper versus LRTIs the concordance index of regression for RSS-HR was 0.91 and RSS-SO was 0.93.
conclusionsRSS-HR distinguishes disease severity based on level of care, as well as LRTI versus URI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.