Evidence map›Paper›PMID 26868041›Full record

ReviewCurrent opinion in neurobiology2016

Canonical computations of cerebral cortex.

Kenneth D Miller

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026
    Article
  2. Spinal Processing of Spatiotemporally Diverse Tactile Stimuli: Computational Insights into Allodynia and Spinal Cord Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Principles of cortical interactions in modular recurrent networks.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Latent encoding of movement in primary visual cortex.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Top-down modulation in canonical cortical circuits with short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Decomposing Neural Circuit Function into Information Processing Primitives.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Kenneth D MillerCenter for Theoretical Neuroscience, Department of Neuroscience, Swartz Program in Theoretical Neuroscience, Kavli Institute for Brain Science, College of Physicians and Surgeons, Columbia University, New York, NY 10032-2695, United States. Electronic address: ken@neurotheory.columbia.edu.

Funding

Models of visual cortical circuitry and developmentR01EY011001 · NEI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MILLER, KENNETH D · 1994 to 2010
$2.5M
NEI NIH HHS R01 EY011001
6 · The paper itself

Abstract

The idea that there is a fundamental cortical circuit that performs canonical computations remains compelling though far from proven. Here we review evidence for two canonical operations within sensory cortical areas: a feedforward computation of selectivity; and a recurrent computation of gain in which, given sufficiently strong external input, perhaps from multiple sources, intracortical input largely, but not completely, cancels this external input. This operation leads to many characteristic cortical nonlinearities in integrating multiple stimuli. The cortical computation must combine such local processing with hierarchical processing across areas. We point to important changes in moving from sensory cortex to motor and frontal cortex and the possibility of substantial differences between cortex in rodents vs. species with columnar organization of selectivity.

Indexed as

Models, NeurologicalAnimalsCerebral Cortex

Identifiers

PMID26868041
PMCPMC4944655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.