ArticleReproductive toxicology (Elmsford, N.Y.)2016
Phthalate metabolite levels and menopausal hot flashes in midlife women.
Article in Reproductive toxicology (Elmsford, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
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Who cites it
28 citing papers in PubMed.
- Urinary phthalate metabolite concentrations and oxidative stress biomarkers in pre- and perimenopausal women from the Midlife Women's Health Study.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- A cross-sectional study of environmental quality and the timing of menarche and menopause in India using national survey and environmental monitoring datasets.Communications medicine · 2026Article
- Mechanisms of Phthalate-Induced Accelerated Ovarian Aging in Experimental Models.Current environmental health reports · 2026Review
- Epidemiologically relevant phthalate mixture and mono(2-ethyl-5-hydroxyhexyl) phthalate exposure alter cell energy metabolism in primary mouse granulosa cells.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Single-cell RNA-seq reveals that granulosa cells are a target of phthalate toxicity in the ovary.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Dietary exposure to di(2-ethylhexyl) phthalate for 6 months alters markers of female reproductive aging in mice†.Biology of reproduction · 2025Article
- Impact of Real-life Environmental Exposures on Reproduction: Endocrine-disrupting chemicals, reproductive aging, and menopause.Reproduction (Cambridge, England) · 2024Review
- Year-to-year variation in phthalate metabolites in the Midlife Women's Health Study.Journal of exposure science & environmental epidemiology · 2024Article
- Phthalates and sex steroid hormones across the perimenopausal period: A longitudinal analysis of the Midlife Women's Health Study.Environment international · 2024Article
- Cross-sectional associations between phthalates, phenols, and parabens with metabolic syndrome risk during early-to-mid adolescence among a cohort of Mexican youth.Environmental research · 2023Article
- Long-term exposure to di(2-ethylhexyl) phthalate, diisononyl phthalate, and a mixture of phthalates alters estrous cyclicity and/or impairs gestational index and birth rate in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Urinary phthalate metabolite concentrations and hot flash outcomes: Longitudinal associations in the Midlife Women's Health Study.Environmental research · 2023Article
- Parabens and Menopause-Related Health Outcomes in Midlife Women: A Pilot Study.Journal of women's health (2002) · 2022Article
- The face behind the Covid-19 mask - A comprehensive review.Environmental technology & innovation · 2022Review
- Article
- The Effects of Environmental Contaminant Exposure on Reproductive Aging and the Menopause Transition.Current environmental health reports · 2022Review
- Urinary phthalate metabolite concentrations and serum hormone levels in pre- and perimenopausal women from the Midlife Women's Health Study.Environment international · 2021Article
- Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women.Environmental research · 2021Article
- Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.Advances in pharmacology (San Diego, Calif.) · 2021Article
- Association of phthalate exposure and endogenous hormones with self-reported sleep disruptions: results from the Midlife Women's Health Study.Menopause (New York, N.Y.) · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
During the menopausal transition, a woman's reproductive capacity declines, her hormone milieu changes, and her risk of hot flashes increases. Exposure to phthalates, which can be found in personal care products, can also result in altered reproductive function. Here, we investigated the associations between phthalate metabolite levels and midlife hot flashes. Eligible women (45-54 years of age) provided detailed information on hot flashes history and donated urine samples (n=195). Urinary phthalate metabolite levels were measured by HPLC-MS/MS. A higher total sum of phthalate metabolites commonly found in personal care products was associated with an increased risk of ever experiencing hot flashes (odds ratio (OR)=1.45; 95% confidence interval (CI)=1.07-1.96), hot flashes in the past 30days (OR=1.43; 95%CI=1.04-1.96), and more frequent hot flashes (OR=1.47; 95%CI=1.06-2.05). These data suggest that some phthalate exposures from personal care products are associated with menopausal hot flashes in women.
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