Evidence map›Paper›PMID 26867802›Full record

Trial reportIntegrative cancer therapies2016

Examining Mediators and Moderators of Yoga for Women With Breast Cancer Undergoing Radiotherapy.

Chelsea G Ratcliff, Kathrin Milbury, Kavita D Chandwani, Alejandro Chaoul, George Perkins, Raghuram Nagarathna, Robin Haddad, Hongasandra Ramarao Nagendra, N V Raghuram, Amy Spelman and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Integrative cancer therapies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Effects of yoga on depressive symptoms in breast cancer patients: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  15. The effectiveness of exercise and/or nutritional interventions to improve the quality of life of women with breast cancer receiving radiation therapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chelsea G RatcliffCenter for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center, Houston, TX, USA Baylor College of Medicine, Houston, TX, USA VA South Central Mental Illness Research, Education, and Clinical Center, Houston, TX, USA.
Kathrin MilburyThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kavita D ChandwaniUniversity of Rochester Medical School, Rochester, NY, USA.
Alejandro ChaoulThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
George PerkinsThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Raghuram NagarathnaSwami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, India.
Robin HaddadThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hongasandra Ramarao NagendraSwami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, India.
N V RaghuramSwami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, India.
Amy SpelmanThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Banu ArunThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Qi WeiThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lorenzo CohenThe University of Texas MD Anderson Cancer Center, Houston, TX, USA lcohen@mdanderson.org.

Funding

R25 SUPPLEMENT IN GENETIC EPIDEMIOLOGY EDUCATIONR25CA057730 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHANG, SHINE · 1992 to 2016
$18.6M
Yoga for women with breast cancer undergoing radiotherapyR01CA138800 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI COHEN, LORENZO · 2010 to 2015
$4.1M
Couple-Based Mind-Body Program for Lung Cancer Patients and their PartnersK01AT007559 · NCCIH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILBURY, KATHRIN · 2013 to 2017
$652k
Biobehavioral Effects of Yoga During Cancer TreatmentR21CA102385 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI COHEN, LORENZO · 2005 to 2007
$511k
NCCIH NIH HHS K01 AT007559NCI NIH HHS R01 CA138800NCI NIH HHS R21 CA102385NCI NIH HHS R25 CA057730
6 · The paper itself

Abstract

Hypothesis This study examines moderators and mediators of a yoga intervention targeting quality-of-life (QOL) outcomes in women with breast cancer receiving radiotherapy.Methods Women undergoing 6 weeks of radiotherapy were randomized to a yoga (YG; n = 53) or stretching (ST; n = 56) intervention or a waitlist control group (WL; n = 54). Depressive symptoms and sleep disturbances were measured at baseline. Mediator (posttraumatic stress symptoms, benefit finding, and cortisol slope) and outcome (36-item Short Form [SF]-36 mental and physical component scales [MCS and PCS]) variables were assessed at baseline, end-of-treatment, and 1-, 3-, and 6-months posttreatment. Results Baseline depressive symptoms (P = .03) and sleep disturbances (P < .01) moderated the Group × Time effect on MCS, but not PCS. Women with high baseline depressive symptoms in YG reported marginally higher 3-month MCS than their counterparts in WL (P = .11). Women with high baseline sleep disturbances in YG reported higher 3-months MCS than their counterparts in WL (P < .01) and higher 6-month MCS than their counterparts in ST (P = .01). YG led to greater benefit finding than ST and WL across the follow-up (P = .01). Three-month benefit finding partially mediated the effect of YG on 6-month PCS. Posttraumatic stress symptoms and cortisol slope did not mediate treatment effect on QOL. Conclusion Yoga may provide the greatest mental-health-related QOL benefits for those experiencing pre-radiotherapy sleep disturbance and depressive symptoms. Yoga may improve physical-health-related QOL by increasing ability to find benefit in the cancer experience.

Indexed as

Breast NeoplasmsDepressionFatigueFemaleHumansHydrocortisoneMeditationMiddle AgedQuality of LifeSleep Wake DisordersYogaHydrocortisonebreast cancermediationmoderationQOLyoga

Identifiers

PMID26867802
PMCPMC4972683

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.