Evidence map›Paper›PMID 26867787›Full record

ReviewTrends in biotechnology2016

Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair.

Barbara J Klotz, Debby Gawlitta, Antoine J W P Rosenberg, Jos Malda, Ferry P W Melchels

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 298 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
298citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

298 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. 3D Printing Strategies for Bioengineering Human Cornea.Advanced healthcare materials · 2026
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238 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Barbara J KlotzDepartment of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, PO 85500, Utrecht, GA, 3508, The Netherlands.
Debby GawlittaDepartment of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, PO 85500, Utrecht, GA, 3508, The Netherlands.
Antoine J W P RosenbergDepartment of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, PO 85500, Utrecht, GA, 3508, The Netherlands.
Jos MaldaDepartment of Orthopaedics, University Medical Center Utrecht, PO Box 85500, Utrecht, GA, 3508, The Netherlands; Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, Utrecht, CM, 3584, The Netherlands. Electronic address: j.malda@umcutrecht.nl.
Ferry P W MelchelsDepartment of Orthopaedics, University Medical Center Utrecht, PO Box 85500, Utrecht, GA, 3508, The Netherlands; Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.

Funding

European Research Council 647426
6 · The paper itself

Abstract

Research over the past decade on the cell-biomaterial interface has shifted to the third dimension. Besides mimicking the native extracellular environment by 3D cell culture, hydrogels offer the possibility to generate well-defined 3D biofabricated tissue analogs. In this context, gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention. This interest is sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorability of photo-crosslinkable hydrogels. GelMA is a versatile matrix that can be used to engineer tissue analogs ranging from vasculature to cartilage and bone. Convergence of biological and biofabrication approaches is necessary to progress from merely proving cell functionality or construct shape fidelity towards regenerating tissues. GelMA has a critical pioneering role in this process and could be used to accelerate the development of clinically relevant applications.

Indexed as

Biocompatible MaterialsGelatinHydrogelsMethacrylatesAnimalsCartilageHumansMiceTissue EngineeringWound HealingBiocompatible MaterialsGelatinHydrogelsMethacrylatesbiofabricationgelatin-methacryloylhydrogelphoto-crosslinkingregenerative medicinetissue engineering

Identifiers

PMID26867787
PMCPMC5937681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.