Evidence map›Paper›PMID 26867647›Full record

ArticleGenetics, selection, evolution : GSE2016

Genomic prediction of unordered categorical traits: an application to subpopulation assignment in German Warmblood horses.

Claas Heuer, Christoph Scheel, Jens Tetens, Christa Kühn, Georg Thaller

Abstract read
In one paragraph

Article in Genetics, selection, evolution : GSE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genome-Enabled Prediction Methods Based on Machine Learning.Methods in molecular biology (Clifton, N.J.) · 2022
    Pooled it
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  4. Using visual scores for genomic prediction of complex traits in breeding programs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Claas HeuerInstitute of Animal Breeding and Husbandry, University of Kiel, Hermann-Rodewald-Strasse 6, 24098, Kiel, Germany. cheuer@tierzucht.uni-kiel.de.
Christoph ScheelInstitute of Animal Breeding and Husbandry, University of Kiel, Hermann-Rodewald-Strasse 6, 24098, Kiel, Germany. cscheel@tierzucht.uni-kiel.de.
Jens TetensInstitute of Animal Breeding and Husbandry, University of Kiel, Hermann-Rodewald-Strasse 6, 24098, Kiel, Germany. jtetens@tierzucht.uni-kiel.de.
Christa KühnInstitute for Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany. kuehn@fbn-dummerstorf.de.
Georg ThallerInstitute of Animal Breeding and Husbandry, University of Kiel, Hermann-Rodewald-Strasse 6, 24098, Kiel, Germany. gthaller@tierzucht.uni-kiel.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCategorical traits without ordinal representation of classes do not qualify for threshold models. Alternatively, the multinomial problem can be assessed by a sequence of independent binary contrasts using schemes such as one-vs-all or one-vs-one. Class probabilities can be arrived at by normalization or pair-wise coupling strategies. We assessed the predictive ability of whole-genome regression models and support vector machines for the classification of horses into four German Warmblood breeds.

resultsPrediction accuracies of leave-one-out cross-validation were high and ranged from 0.75 to 0.97 depending on the binary classifier and breeds incorporated in the training. An analysis of the population structure using eigenvectors of the genomic relationship matrix revealed clustering of individuals beyond the given breed labels. Admixture between two breeds became apparent which had substantial impact on the prediction accuracies between those two breeds and also influenced the contrasts between other breeds.

conclusionsGenomic prediction of unordered categorical traits was successfully applied to subpopulation assignment of German Warmblood horses. The applied methodology is a straightforward extension of existing binary threshold models for genomic prediction.

Indexed as

BreedingModels, GeneticQuantitative Trait, HeritableAnimalsBayes TheoremGenetics, PopulationGenomeGenomicsGenotypeGermanyHorsesPhenotypePolymorphism, Single NucleotideRegression AnalysisSupport Vector Machine

Identifiers

PMID26867647
PMCPMC4751658

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.