Evidence map›Paper›PMID 26867646›Full record

ArticlePathogens and disease2016

Specific polymorphisms in the vitamin D metabolism pathway are not associated with susceptibility to Chlamydia trachomatis infection in humans.

Esmée Lanjouw, Ivan Branković, Jolein Pleijster, Joke Spaargaren, Christian J P A Hoebe, Henk J van Kranen, Sander Ouburg, Servaas A Morré

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In one paragraph

Article in Pathogens and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Esmée LanjouwDepartment of Dermatology, Erasmus MC, Rotterdam 3015 CA, the Netherlands Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
Ivan BrankovićLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam 1081 BT, the Netherlands Institute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht 6200 MD, the Netherlands.
Jolein PleijsterLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
Joke SpaargarenLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
Christian J P A HoebePublic Health Service South Limburg, Department of Sexual Health, Infectious Disease and Environmental Health, Geleen 6160 HA, the Netherlands Department of Medical Microbiology, Maastricht University, Maastricht 6200 MD, the Netherlands.
Henk J van KranenInstitute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht 6200 MD, the Netherlands National Institute for Public Health and the Environment, Bilthoven 3721 MA, the Netherlands.
Sander OuburgLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam 1081 BT, the Netherlands s.ouburg@vumc.nl.
Servaas A MorréLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam 1081 BT, the Netherlands Institute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht 6200 MD, the Netherlands.

Funding

Identifying Biomarkers and Genetic Risk Factors Predictive of Reproductive SequelR21AI098660 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI · 2012 to 2013
$359k
NIAID NIH HHS 1R21AI.098660-01
6 · The paper itself

Abstract

Chlamydia trachomatis is the most common sexually transmitted bacterium worldwide. Its often asymptomatic course of infection increases chances of transmission, and increases risk of late complications. Genetic variations in the host immune system are known to impact the course of infections. Recent studies have shown a positive impact of vitamin D on the regulation of the immune system. This study assesses the impact of eight polymorphisms in five genes [VDR (rs1544410 G > A, rs2228570 C > T), CYP27B1 (rs10877012 G > T), DHCR7 (rs7944926 G > A, rs3829251 G > A), GC (rs3755967) and CYP2R1 (rs10741657 G > A, rs2060793 G > A)] on susceptibility to Chlamydia infections in humans. These polymorphisms could influence protein expression or function, and thus influence the immune system. Samples of women visiting the STD outpatient clinic in South Limburg were genotyped using the Roche Lightcycler 480. In this study, we did not observe statistically significant differences between the genotype distributions of these polymorphisms in women with or without a Chlamydia infection. This suggests that VDR, CYP27B1, DHCR7, GC and CYP2R1 do not affect the susceptibility to Chlamydia infections. However, due to its pleiotropic nature in the immune system a role for the vitamin D pathway may not be excluded from the whole clinical course of Chlamydia infections (e.g. late complications), and further research is required.

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseCase-Control StudiesChlamydia InfectionsChlamydia trachomatisCholestanetriol 26-MonooxygenaseCytochrome P450 Family 2FemaleGenetic Predisposition to DiseaseGenotypeHumansOxidoreductases Acting on CH-CH Group DonorsPolymorphism, Single NucleotideReceptors, CalcitriolVitamin D25-Hydroxyvitamin D3 1-alpha-Hydroxylase7-dehydrocholesterol reductaseCholestanetriol 26-MonooxygenaseCYP27B1 protein, humanCYP2R1 protein, humanCytochrome P450 Family 2Oxidoreductases Acting on CH-CH Group DonorsReceptors, CalcitriolVDR protein, humanVitamin DChlamydia trachomatisinfectionsusceptibilityvitamin D

Identifiers

PMID26867646
PMCPMC5975236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.