Evidence map›Paper›PMID 26867608›Full record

ArticlePediatric radiology2016

Detecting inflammation in the unprepared pediatric colon - how reliable is magnetic resonance enterography?

Joy L Barber, Adriana Chebar Lozinsky, Fevronia Kiparissi, Neil Shah, Tom A Watson

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joy L BarberDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.
Adriana Chebar LozinskyDepartment of Gastroenterology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Fevronia KiparissiDepartment of Gastroenterology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Neil ShahDepartment of Gastroenterology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Tom A WatsonDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK. tom.watson@gosh.nhs.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric inflammatory bowel disease frequently affects the colon. MR enterography is used to assess the small bowel but it also depicts the colon.

objectiveTo compare the accuracy of MR enterography and direct visualization at endoscopy in assessing the colon in pediatric inflammatory bowel disease. MATERIALS AND

methodsWe included children with inflammatory bowel disease who had undergone both MR enterography and endoscopy, and we restrospectively assessed the imaging and endoscopic findings. We scored the colonic appearance at MR using a total colon score. We then compared scores for the whole colon and for its individual segments with endoscopy and histology.

resultsWe included 15 children. An elevated MR colonic segmental score predicted the presence of active inflammation on biopsy with a specificity of 90% (95% confidence interval [CI] 79.5-96.2%) and sensitivity of 60% (CI 40.6-77.3%); this compares reasonably with the predictive values for findings at colonoscopy - specificity 85% (CI 73.4-92.9%) and sensitivity 53.3% (CI 34.3%-71.6%). Accuracy did not change significantly with increasing bowel distension.

conclusionMR-derived scores had comparable accuracy to those derived during visualization at colonoscopy for detecting biopsy-proven inflammation in our patient group. MR enterography might prove useful in guiding biopsy or monitoring treatment response. Collapse of a colonic segment did not impair assessment of inflammation.

Indexed as

AdolescentBiopsyChildChild, PreschoolColonoscopyDiagnosis, DifferentialFemaleHumansInflammatory Bowel DiseasesMagnetic Resonance ImagingMalePredictive Value of TestsRetrospective StudiesSensitivity and SpecificityAdolescentChildColonoscopyInflammatory bowel diseaseMagnetic resonance enterographyMagnetic resonance imaging

Identifiers

PMID26867608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.