ArticleJournal of thrombosis and thrombolysis2016
Atypical presentations of thrombotic thrombocytopenic purpura: a diagnostic role for ADAMTS13.
Article in Journal of thrombosis and thrombolysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Uncommon Manifestation: Thrombotic Thrombocytopenic Purpura Presenting Solely as Petechial Rash.Cureus · 2024Article
- Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with possible complication of thrombotic microangiopathy.The Journal of dermatology · 2024Article
- Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura.Case reports in medicine · 2023Article
- Thrombotic Thrombocytopenic Purpura Triggered by Acute Myeloid Leukemia: A Case Report.The American journal of case reports · 2022Article
- A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes.Clinics and practice · 2021Article
- Atypical Presentation of Thrombotic Thrombocytopenic Purpura without Hematological Features.International journal of hematology-oncology and stem cell research · 2020Article
- [Progress of acquired thrombotic thrombocytopenic purpura].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- An improbable and unusual case of thrombotic thrombocytopenia purpura.Journal of community hospital internal medicine perspectives · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombotic thrombocytopenic purpura (TTP) is an acute, life threatening disease. Only a minority of patients expresses the complete clinical presentation and unusual manifestations can occur. Demonstration of low activity levels of ADAMTS13 (<5 %) is highly specific for the diagnosis of TTP. This study reports a series of five cases of TTP presenting with a thrombotic event and no hematological findings. Detailed chart reviews on these patients were conducted. We identified two patients whose first attack of TTP presented as a thrombotic episode without microangiopathic hemolytic anemia and thrombocytopenia, only to be diagnosed as TTP days later, after the appearance of hematological signs. We also describe three cases of classical TTP relapsing atypically as cerebrovascular accidents without hematological signs. Low levels of ADAMTS13 activity were detected and facilitated the diagnosis. The neurological manifestations disappeared concurrent with normalization of ADAMTS13 activity level after plasma exchange. This study underscores the importance of having a high clinical suspicion of TTP in cases of thrombosis even without hematological abnormalities in patients with previous attacks of TTP. In this clinical scenario, measurement of ADAMTS13 activity is important for diagnosis and early administration of treatment.
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