Trial reportScientific reports2016
Activation and Connectivity within the Default Mode Network Contribute Independently to Future-Oriented Thought.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The neurobiology of internet addiction: a scoping review of developmental and gender-specific mechanisms.Frontiers in psychology · 2026Pooled it
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Reduced task-switching flexibility in parietal-cingulate and frontal circuits associated with brooding.Cognitive neurodynamics · 2026Article
- Reward sensitivity is negatively associated with future self-continuity: the mediation role of functional connectivity between the dorsomedial prefrontal cortex and ventrolateral prefrontal cortex.Brain structure & function · 2026Article
- On the Same Wavelength: The Relationship between Neural Synchrony and Cognitive Ability during Movie Watching in Late Childhood and Early Adolescence.Developmental neuroscience · 2026Article
- Medial prefrontal activation as a neural predictor of cognitive training gains in older adults with amnestic mild cognitive impairment: exploratory evidence.Frontiers in aging neuroscience · 2026Article
- EEG Microstate Alterations in Anhedonia Subtypes of Major Depressive Disorder and Their Modulation by Intermittent Theta-Burst Stimulation.Depression and anxiety · 2026Article
- Exercise intervention for rumination: from neural mechanisms to clinical applications.Frontiers in psychology · 2026Review
- Abstinence Alters Triple Network Dynamics in Moderate-to-Heavy Drinkers.Human brain mapping · 2025Article
- Cortical connectivity in speech and sensory networks associated with childrens' listening and attention disorders.medRxiv : the preprint server for health sciences · 2025Article
- Platform Technology for Extended Reality Biofeedback Training Under Operant Conditioning for Functional Limb Weakness: Protocol for the Coproduction of an at-Home Solution (React2Home).JMIR research protocols · 2025Article
- A dynamic framework of brain functional patterns shaped by spontaneous thoughts beyond the default mode network.Scientific reports · 2025Article
- Spatio-Temporal Signatures of Cognitive Function After Pediatric Arterial Ischemic Stroke-A Pilot Study.Human brain mapping · 2025Article
- Neural Signatures of Cognitive Control Predict Future Adolescent Substance Use Onset and Frequency.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Neurocomputational Mechanisms of Sense of Agency: Literature Review for Integrating Predictive Coding and Adaptive Control in Human-Machine Interfaces.Brain sciences · 2025Review
- Apparent Diffusion Coefficient fMRI shines light on white matter resting-state connectivity compared to BOLD.Communications biology · 2025Article
- Superiority illusion in older adults: Volume and functional connectivity of the precuneus.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Alzheimer's disease-like features in resting state EEG/fMRI of cognitively intact and healthy middle-agedJournal of Alzheimer's disease : JAD · 2025Article
- The neural activity of auditory conscious perception.NeuroImage · 2025Article
- Vivid imagery of objects primes perception of subliminal spatial information.Neuroscience of consciousness · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Future-oriented thought, a projection of the self into the future to pre-experience an event, has been linked to default mode network (DMN). Previous studies showed that the DMN was generally divided into two subsystems: anterior part (aDMN) and posterior part (pDMN). The former is mostly related to self-referential mental thought and latter engages in episodic memory retrieval and scene construction. However, functional contribution of these two subsystems and functional connectivity between them during future-oriented thought has rarely been reported. Here, we investigated these issues by using an experimental paradigm that allowed prospective, episodic decisions concerning one's future (Future Self) to be compared with self-referential decisions about one's immediate present state (Present Self). Additionally, two parallel control conditions that relied on non-personal semantic knowledge (Future Non-Self Control and Present Non-Self Control) were conducted. Our results revealed that the aDMN was preferentially activated when participants reflected on their present states, whereas the pDMN exhibited preferentially activation when participants reflected on their personal future. Intriguingly, significantly decreased aDMN-pDMN connectivity was observed when thinking about their future relative to other conditions. These results support the notion that activation within these subsystems and connectivity between them contribute differently to future-oriented thought.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.