Evidence map›Paper›PMID 26867200›Full record

Trial reportNutrients2016

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults.

Philippa A Jackson, Joanne S Forster, J Gordon Bell, James R Dick, Irene Younger, David O Kennedy

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  14. Observational
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  17. Impact of Dietary Fats on Brain Functions.Current neuropharmacology · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Philippa A JacksonBrain, Performance and Nutrition Research Centre, Northumbria University, Newcastle-upon-Tyne NE1 8ST, UK. philippa.jackson@northumbria.ac.uk.
Joanne S ForsterBrain, Performance and Nutrition Research Centre, Northumbria University, Newcastle-upon-Tyne NE1 8ST, UK. jo.forster@northumbria.ac.uk.
J Gordon BellInstitute of Aquaculture, University of Stirling, Stirlingshire FK9 4LA, UK. g.j.bell@stir.ac.uk.
James R DickInstitute of Aquaculture, University of Stirling, Stirlingshire FK9 4LA, UK. j.r.dick@stir.ac.uk.
Irene YoungerInstitute of Aquaculture, University of Stirling, Stirlingshire FK9 4LA, UK. Irene.younger@stir.ac.uk.
David O KennedyBrain, Performance and Nutrition Research Centre, Northumbria University, Newcastle-upon-Tyne NE1 8ST, UK. david.kennedy@northumbria.ac.uk.
Northumbria University · GBUniversity of Stirling · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of recent trials have demonstrated positive effects of dietary supplementation with the omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on measures of cognitive function in healthy young and older adults. One potential mechanism by which EPA, and DHA in particular, may exert these effects is via modulation of cerebral hemodynamics. In order to investigate the effects of DHA alone or provided as one component of a multinutrient supplement (also including Gingko biloba, phosphatidylserine and vitamins B₉ and B₁₂) on measures of cerebral hemodynamics and cognitive function, 86 healthy older adults aged 50-70 years who reported subjective memory deficits were recruited to take part in a six month daily dietary supplementation trial. Relative changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin were assessed using Near Infrared Spectroscopy (NIRS) during the performance of cognitive tasks prior to and following the intervention period. Performance on the cognitive tasks was also assessed. No effect of either active treatment was found for any of the NIRS measures or on the cognitive performance tasks, although the study was limited by a number of factors. Further work should continue to evaluate more holistic approaches to cognitive aging.

Indexed as

Dietary SupplementsMemory DisordersBrainCognitionDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFemaleGinkgo bilobaHemodynamicsHemoglobinsHumansMaleMiddle AgedOxygenPhosphatidylserinesDocosahexaenoic AcidsEicosapentaenoic AcidHemoglobinsOxygenPhosphatidylserinesVitamin B Complexcerebral blood flowcognitive declineDHAEPANIRSomega-3 polyunsaturated fatty acids

Identifiers

PMID26867200
PMCPMC4772049
OpenAlexW2253888111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.