ArticleCell host & microbe2016
Selective Bottlenecks Shape Evolutionary Pathways Taken during Mammalian Adaptation of a 1918-like Avian Influenza Virus.
Article in Cell host & microbe, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 66 citations in OpenAlex.
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- Standing HA phenotypic breadth shapes H5N1 cross-host potential.Research square · 2026Article
- Weak selection and stochastic processes limit the emergence of antigenic variants during household transmission of influenza A viruses.PLoS pathogens · 2026Article
- Weak selection and stochastic processes limit the emergence of antigenic variants during household transmission of influenza A viruses.bioRxiv : the preprint server for biology · 2025Article
- Infectivity in full-term placenta of Zika viruses with different lipid profiles.Virus research · 2025Article
- Spillover: Mechanisms, Genetic Barriers, and the Role of Reservoirs in Emerging Pathogens.Microorganisms · 2024Review
- Reply to: Population genetic considerations regarding the interpretation of within-patient SARS-CoV-2 polymorphism data.Nature communications · 2024Article
- Influenza A Virus Multicycle Replication Yields Comparable Viral Population Emergence in Human Respiratory and Ocular Cell Types.Microbiology spectrum · 2023Article
- A Selective Bottleneck During Host Entry Drives the Evolution of New Legume Symbionts.Molecular biology and evolution · 2023Article
- Host-Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans.Viruses · 2023Review
- Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals.Virus evolution · 2023Article
- Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene.Journal of virology · 2022Article
- Article
- Variable routes to genomic and host adaptation among coronaviruses.Journal of evolutionary biology · 2021Article
- Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck.PLoS pathogens · 2021Article
- Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck.bioRxiv : the preprint server for biology · 2021Article
- Cross-scale dynamics and the evolutionary emergence of infectious diseases.Virus evolution · 2021Article
- Spatial and temporal coevolution of N2 neuraminidase and H1 and H3 hemagglutinin genes of influenza A virus in US swine.Virus evolution · 2021Article
- Asynchrony between virus diversity and antibody selection limits influenza virus evolution.eLife · 2020Article
- Bat-borne virus diversity, spillover and emergence.Nature reviews. Microbiology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Avian influenza virus reassortants resembling the 1918 human pandemic virus can become transmissible among mammals by acquiring mutations in hemagglutinin (HA) and polymerase. Using the ferret model, we trace the evolutionary pathway by which an avian-like virus evolves the capacity for mammalian replication and airborne transmission. During initial infection, within-host HA diversity increased drastically. Then, airborne transmission fixed two polymerase mutations that do not confer a detectable replication advantage. In later transmissions, selection fixed advantageous HA1 variants. Transmission initially involved a "loose" bottleneck, which became strongly selective after additional HA mutations emerged. The stringency and evolutionary forces governing between-host bottlenecks may therefore change throughout host adaptation. Mutations occurred in multiple combinations in transmitted viruses, suggesting that mammalian transmissibility can evolve through multiple genetic pathways despite phenotypic constraints. Our data provide a glimpse into avian influenza virus adaptation in mammals, with broad implications for surveillance on potentially zoonotic viruses.
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