ArticleArthritis care & research2016
Association of Anticentromere Antibodies With More Severe Exocrine Glandular Dysfunction in Sjögren's Syndrome: Analysis of the Sjögren's International Collaborative Clinical Alliance Cohort.
Article in Arthritis care & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Identifying the clinical signature of anti-centromere antibody-positive Sjögren's syndrome: a machine learning-based analysis of a multicenter cohort.Frontiers in immunology · 2026Article
- Anti-centromere protein B antibody positivity in primary Sjögren's disease: clinical features and prognostic implications.Frontiers in immunology · 2026Article
- Non-Conventional and Emerging Autoantibodies in Sjögren's Disease.Journal of inflammation research · 2026Review
- Anti-CENP-B polarity divides SLE: divergent clinical-immune phenotypes and distinct treatment responses.Frontiers in immunology · 2026Article
- Sjögren's Syndrome: Epidemiology, Classification Criteria, Molecular Pathogenesis, Diagnosis, and Treatment.MedComm · 2025Review
- Chilblains With Tumid Lupus Features in a Patient With Sjögren's Syndrome: A Case Report.Cureus · 2025Article
- Ultrasound shear wave elastography for assessing minor salivary gland involvement in anti-centromere antibody-positive primary Sjögren's syndrome: a retrospective study.Clinical and experimental medicine · 2024Review
- [Clinical and immunological features of primary Sjögren's syndrome patients with positive anti-centromere protein B antibody].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Prevalence and Clinical Implications of Scleroderma-Specific Autoantibodies in Seronegative Patients with Sicca Complaints.Mediterranean journal of rheumatology · 2023Article
- Anti-SSA/SSB-negative primary Sjögren's syndrome showing different clinical phenotypes: a retrospective study of 934 cases.Advances in rheumatology (London, England) · 2023Article
- The Diagnosis, Treatment, and Clinical Sequelae of Sjogren's Syndrome in a Pediatric Patient: A Case Report.Cureus · 2023Article
- Hypocomplementemia in primary Sjogren's syndrome: association with serological, clinical features, and outcome.Clinical rheumatology · 2022Article
- Sjögren syndrome: looking forward to the future.Therapeutic advances in musculoskeletal disease · 2022Review
- Clinical influences of anticentromere antibody on primary Sjögren's syndrome in a prospective Korean cohort.The Korean journal of internal medicine · 2021Article
- Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.PloS one · 2021Article
- Development of anti-centromere antibody-positive autoimmune hepatitis after childbirth.Clinical journal of gastroenterology · 2020Article
- Clinical and Immunological Features of Anti-centromere Antibody-Positive Primary Sjögren's Syndrome.Rheumatology and therapy · 2018Article
- Update on Sjögren Syndrome and Other Causes of Sicca in Older Adults.Rheumatic diseases clinics of North America · 2018Review
- Subgroups of Sjögren's syndrome patients categorised by serological profiles: clinical and immunological characteristics.Reumatologia · 2018Article
- Sjögren Syndrome and Other Causes of Sicca in Older Adults.Clinics in geriatric medicine · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAnticentromere antibodies (ACAs) define a subset of primary Sjögren's syndrome (SS) with a unique phenotype, including features of limited cutaneous systemic sclerosis and a lower frequency of anti-SSA/SSB antibodies. We sought to determine whether ACAs are associated with more severe exocrine glandular dysfunction in a large cohort of primary SS subjects.
methodsWe performed a cross-sectional analysis of 1,361 subjects with primary SS from the Sjögren's International Collaborative Clinical Alliance Registry, stratified by the presence or absence of ACAs. ACAs were assayed by immunofluorescence staining on HEp-2 cells.
resultsACAs were present in 82 of the 1,361 SS subjects (6%) and were associated with older age, female sex, and lower frequencies of anti-SSA/SSB, rheumatoid factor, and hyperglobulinemia. Among ACA-positive versus ACA-negative subjects, there was a higher frequency of a focus score ≥2 (71% versus 53%; P = 0.002), a higher median focus score (2.8 versus 2.5; P = 0.0440), and greater exocrine gland dysfunction: Schirmer's test value: median 4 versus 5 mm/5 minutes; P = 0.0003, and unstimulated whole saliva (UWS) flow rate: median 0.08 versus 0.37 ml/5 minutes; P < 0.0001. ACA-positive subjects had an increased risk of UWS <0.1 ml/minute (odds ratio [OR] 12.24 [95% confidence interval (95% CI) 4.91-41.02]) and Schirmer's test value <5 mm/5 minutes (OR 2.52 [95% CI 1.50-4.36]) after correcting for age, sex, anti-SSA/SSB, and focus score. Labial gland fibrosis was not different between the 2 groups.
conclusionIn a large international registry of SS, ACA had an independent association with more severe exocrine glandular dysfunction. This dysfunction was associated with more pronounced labial salivary glandular inflammation but not fibrosis.
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