ArticlePsychosomatic medicine2016
Positive Affect and Inflammatory Activity in Breast Cancer Survivors: Examining the Role of Affective Arousal.
Article in Psychosomatic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- A pilot investigation of the impact of acute mental and physical fatigue exposure on inflammatory cytokines and state fatigue level in breast cancer survivors.BMC women's health · 2025Trial
- How mindfulness training promotes positive emotions: Dismantling acceptance skills training in two randomized controlled trials.Journal of personality and social psychology · 2018Trial
- A positive emotion regulation intervention for bipolar I disorder: Treatment development and initial outcomes.General hospital psychiatryTrial
- Positive affect and inflammation in women with breast cancer: A systematic review.Brain, behavior, & immunity - health · 2026Review
- The Inflammatory Footprint of Anti-Breast Cancer Treatments and Psychosocial Factors in Women Undergoing Chemotherapy.Biomedicines · 2025Article
- Characteristics of positive and negative effects on the quality of life of breast cancer patients.BMC psychiatry · 2024Article
- The biology of hope: Inflammatory and neuroendocrine profiles in ovarian cancer patients.Brain, behavior, and immunity · 2024Article
- Momentary Emotion Goals and Spontaneous Emotion Regulation in Daily Life: An Ecological Momentary Assessment Study of Desire for High Versus Low Arousal Positive Emotion.Affective science · 2022Article
- [A prospective cohort study of the influence of positive/negative effectivity on the mortality risk of the Chinese elderly].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Review
- Pediatric sickle cell pain-sleep relationships: The roles of positive and negative affect.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021Article
- The longitudinal relationship between changes in wellbeing and inflammatory markers: Are associations independent of depression?Brain, behavior, and immunity · 2020Article
- Cultivating a healthy neuro-immune network: A health psychology approach.Social and personality psychology compass · 2019Article
- Race/Ethnicity Moderates the Association Between Psychosocial Resilience and Movement-Evoked Pain in Knee Osteoarthritis.ACR open rheumatology · 2019Article
- Physician Empathy Interacts with Breaking Bad News in Predicting Lung Cancer and Pleural Mesothelioma Patient Survival: Timing May Be Crucial.Journal of clinical medicine · 2018Article
- Emodiversity and biomarkers of inflammation.Emotion (Washington, D.C.) · 2018Article
- THE ROLE OF PSYCHOLOGICAL WELL-BEING IN BOOSTING IMMUNE RESPONSE: AN OPTIMAL EFFORT FOR TACKLING INFECTION.African journal of infectious diseases · 2018Article
- Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes.Integrative cancer therapiesReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveGiven the importance of positive affect and inflammation for well-being in cancer survivors, the current study examined the relationship between high- and low-arousal positive affect and inflammation in 186 women who completed treatment of early-stage breast cancer.
methodsMeasures of high- and low-arousal positive affect were completed within 3 months after treatment completion (baseline). Plasma markers of inflammation, including soluble tumor necrosis factor receptor type II (sTNF-RII), C-reactive protein (CRP), and interleukin-1 receptor antagonist, were assessed at baseline and 6- and 12-month follow-up assessments.
resultsMultilevel modeling analyses showed that high-arousal positive affect was associated with lower levels of sTNF-RII, a marker of TNF activity, at treatment completion and prospectively predicted maintenance of these differences through the 6- and 12-month follow-ups adjusting for biobehavioral confounds (b = -0.055, t(156) = -2.40, p = .018). However, this association was no longer significant when adjusting for fatigue. Exploratory analyses showed that low-arousal positive affect was associated with lower levels of CRP at treatment completion and through the 6- and 12-month follow-ups; this association remained significant after adjusting for fatigue and other confounds (b = -0.217, t(152) = -2.04, p = .043).
conclusionsThe relationship of high-arousal positive affect (e.g., "active") with sTNF-RII seems to be driven by the overlap of high-arousal positive affect with fatigue, whereas the relationship of low-arousal positive affect (e.g., "calm") with CRP was independent of fatigue. Future research should consider affective arousal when examining the association of positive affect with inflammation as this facet of positive affect may have important implications for interpretation of results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.