ReviewPediatric research2016
Childhood obesity-related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements.
Review in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of Active Video Games in Blood Pressure Management Among Children and Young Adults: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study.Nutrition & diabetes · 2022Trial
- Nigerian youth FitnessGram edge: A bright signal with important caveats.World journal of clinical pediatrics · 2026Article
- Whole blood TNF-α expression and apoptotic endothelial microparticles reveal early vascular injury in pediatric obesity.International journal of obesity (2005) · 2026Article
- Non-Coding RNAs in Obesity-Driven Vascular Dysfunction: Mechanisms, EndMT, and Translational Opportunities.Chonnam medical journal · 2026Review
- Definition and diagnostic criteria of clinical obesity.The lancet. Diabetes & endocrinology · 2025Review
- Exposure to air pollution and cardiovascular risk in young children - a pilot project.Pediatric research · 2024Article
- Ambulatory blood pressure monitoring in children and adolescents post-hematopoietic stem cell transplantation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Vitamin D Supplementation in the Assessment of Cardiovascular Risk Factors in Overweight and Obese Children.Medical sciences (Basel, Switzerland) · 2022Observational
- Multiple non-invasive peripheral vascular function parameters with obesity and cardiometabolic risk indicators in school-aged children.BMC pediatrics · 2022Article
- Predictive Markers of Early Cardiovascular Impairment and Insulin Resistance in Obese Pediatric Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Cardiometabolic risk factors and early indicators of vascular dysfunction: a cross-sectional cohort study in South African adolescents.BMJ open · 2021Article
- Feasibility and Tolerance of Fingertip Peripheral Arterial Tonometry Measurements in School-Aged Children.Frontiers in pediatrics · 2021Article
- Sedentary Behavior in Childhood, Lower Arterial Compliance and Decreased Endothelial Function-Cross Sectional Data From a German School Cohort.Frontiers in pediatrics · 2021Article
- Iron Metabolism in Obesity and Metabolic Syndrome.International journal of molecular sciences · 2020Review
- The cardiovascular risk in paediatrics: the paradigm of the obstructive sleep apnoea syndrome.Blood transfusion = Trasfusione del sangue · 2020Review
- Effect of an 8-Week Individualized Training Program on Blood Biomarkers, Adipokines and Endothelial Function in Obese Young Adolescents with and without Metabolic Syndrome.International journal of environmental research and public health · 2019Article
- Endothelial function in children with white-coat hypertension.Heart and vessels · 2018Article
- Exosomal Cargo Properties, Endothelial Function and Treatment of Obesity Hypoventilation Syndrome: A Proof of Concept Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood obesity jeopardizes a healthy future for our society's children as it is associated with increased cardiovascular morbidity and mortality later on in life. Endothelial dysfunction, the first step in the development of atherosclerosis, is already present in obese children and may well represent a targetable risk factor. Technological advancements in recent years have facilitated noninvasive measurements of endothelial homeostasis in children. Thereby this topic ultimately starts to get the attention it deserves. In this paper, we aim to summarize the latest insights on endothelial dysfunction in childhood obesity. We discuss methodological advancements in peripheral endothelial function measurement and newly identified diagnostic markers of vascular homeostasis. Finally, future challenges and perspectives are set forth on how to efficiently tackle the catastrophic rise in cardiovascular morbidity and mortality that will be inflicted on obese children if they are not treated optimally.
Indexed as
Identifiers
26866906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.