ArticleNeonatology2016
Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs.
Article in Neonatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Accuracy of a battery-powered portable capnometer in premature infants.Journal of clinical monitoring and computing · 2022Article
- Non-invasive carbon dioxide monitoring in neonates: methods, benefits, and pitfalls.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- End-tidal capnography monitoring in infants ventilated on the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Chest Compressions for Bradycardia during Neonatal Resuscitation-Do We Have Evidence?Children (Basel, Switzerland) · 2019Review
- Oxygenation and Hemodynamics during Chest Compressions in a Lamb Model of Perinatal Asphyxia Induced Cardiac Arrest.Children (Basel, Switzerland) · 2019Article
- A family of NICU graduates!Pediatric research · 2018Article
- Effect of various inspired oxygen concentrations on pulmonary and systemic hemodynamics and oxygenation during resuscitation in a transitioning preterm model.Pediatric research · 2018Article
- The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation.Journal of visualized experiments : JoVE · 2018Article
- Continuous capnography monitoring during resuscitation in a transitional large mammalian model of asphyxial cardiac arrest.Pediatric research · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe Neonatal Resuscitation Program (NRP) recommends close monitoring of oxygenation during the resuscitation of newborns using a pulse oximeter. However, there are no guidelines for monitoring carbon dioxide (CO2) to assess ventilation. Considering that cerebral blood flow (CBF) correlates directly with PaCO2, continuous capnography monitoring of end-tidal CO2 (ETCO2) may limit fluctuations in PaCO2 and, therefore, CBF during resuscitation of asphyxiated infants.
objectiveTo evaluate whether continuous monitoring of ETCO2 with capnography during resuscitation of asphyxiated term lambs with meconium aspiration will prevent fluctuations in PaCO2 and carotid arterial blood flow (CABF).
methodsFifty-four asphyxiated term lambs with meconium aspiration syndrome were mechanically ventilated from birth to 60 min of age. Ventilatory parameters were adjusted based on clinical observation (chest excursion) and frequent arterial blood gas analysis in 24 lambs (control group) and 30 lambs (capnography group) received additional continuous ETCO2 monitoring. Left CABF was monitored. We aimed to maintain PaCO2 between 35 and 50 mm Hg and ETCO2 between 30 and 45 mm Hg.
resultsThere was a significant correlation between ETCO2 and PaCO2 (R = 0.7, p < 0.001), between PaCO2 and carotid flow (R = 0.52, p < 0.001) and between ETCO2 and carotid flow (R = 0.5, p < 0.001). PaCO2 and CABF during the first 60 min of age showed significantly higher fluctuation in the control group compared to the capnography group.
conclusionContinuous monitoring of ETCO2 using capnography with mechanical ventilation during and after resuscitation in asphyxiated term lambs with meconium aspiration limits fluctuations in PaCO2 and CABF and may potentially limit brain injury.
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