Evidence map›Paper›PMID 26866481›Full record

ArticlePloS one2016

Long-Term Shedding of Influenza Virus, Parainfluenza Virus, Respiratory Syncytial Virus and Nosocomial Epidemiology in Patients with Hematological Disorders.

Nicola Lehners, Julia Tabatabai, Christiane Prifert, Marianne Wedde, Joe Puthenparambil, Benedikt Weissbrich, Barbara Biere, Brunhilde Schweiger, Gerlinde Egerer, Paul Schnitzler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nicola LehnersDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Julia TabatabaiDepartment of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
Christiane PrifertInstitute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Marianne WeddeNational Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany.
Joe PuthenparambilDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Benedikt WeissbrichInstitute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Barbara BiereNational Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany.
Brunhilde SchweigerNational Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany.
Gerlinde EgererDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Paul SchnitzlerDepartment of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
Heidelberg University · DERobert Koch Institute · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory viruses are a cause of upper respiratory tract infections (URTI), but can be associated with severe lower respiratory tract infections (LRTI) in immunocompromised patients. The objective of this study was to investigate the genetic variability of influenza virus, parainfluenza virus and respiratory syncytial virus (RSV) and the duration of viral shedding in hematological patients. Nasopharyngeal swabs from hematological patients were screened for influenza, parainfluenza and RSV on admission as well as on development of respiratory symptoms. Consecutive swabs were collected until viral clearance. Out of 672 tested patients, a total of 111 patients (17%) were infected with one of the investigated viral agents: 40 with influenza, 13 with parainfluenza and 64 with RSV; six patients had influenza/RSV or parainfluenza/RSV co-infections. The majority of infected patients (n = 75/111) underwent stem cell transplantation (42 autologous, 48 allogeneic, 15 autologous and allogeneic). LRTI was observed in 48 patients, of whom 15 patients developed severe LRTI, and 13 patients with respiratory tract infection died. Phylogenetic analysis revealed a variety of influenza A(H1N1)pdm09, A(H3N2), influenza B, parainfluenza 3 and RSV A, B viruses. RSV A was detected in 54 patients, RSV B in ten patients. The newly emerging RSV A genotype ON1 predominated in the study cohort and was found in 48 (75%) of 64 RSV-infected patients. Furthermore, two distinct clusters were detected for RSV A genotype ON1, identical RSV G gene sequences in these patients are consistent with nosocomial transmission. Long-term viral shedding for more than 30 days was significantly associated with prior allogeneic transplantation (p = 0.01) and was most pronounced in patients with RSV infection (n = 16) with a median duration of viral shedding for 80 days (range 35-334 days). Long-term shedding of respiratory viruses might be a catalyzer of nosocomial transmission and must be considered for efficient infection control in immunocompromised patients.

Indexed as

Virus SheddingAdultAgedAged, 80 and overCohort StudiesCommunicable Disease ControlCross InfectionFemaleGenotypeHematologic DiseasesHumansInfluenza, HumanMaleMiddle AgedMutationNose

Identifiers

PMID26866481
PMCPMC4750950
OpenAlexW2263763112

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.