ArticleNanoscale2016
C60 fullerene localization and membrane interactions in RAW 264.7 immortalized mouse macrophages.
Article in Nanoscale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Insight into the interactions of fullerenes with biological membranes through molecular dynamics simulations.Advances in physics: X · 2024Article
- Electron-decoupled MAS DNP with N@CPhysical chemistry chemical physics : PCCP · 2023Article
- Silent Death by Sound: CInternational journal of molecular sciences · 2023Article
- Anti-Inflammatory and Antioxidant Effects of Liposoluble C60 at the Cellular, Molecular, and Whole-Animal Levels.Journal of inflammation research · 2023Article
- State-of-the-Art of Polymer/Fullerene CMembranes · 2022Review
- Quenching of Protein Fluorescence by Fullerenol CInternational journal of molecular sciences · 2022Article
- Article
- Self-assembly of ultra-small-sized carbon nanoparticles in lipid membrane disrupts its integrity.Nanoscale advances · 2021Article
- Analysis of Biomechanical Parameters of Muscle Soleus Contraction and Blood Biochemical Parameters in Rat with Chronic Glyphosate Intoxication and Therapeutic Use of CInternational journal of molecular sciences · 2021Article
- Autophagy modulating agents as chemosensitizers for cisplatin therapy in cancer.Investigational new drugs · 2021Review
- Combustion by-products and their health effects: Summary of the 16th international congress.Fuel (London, England) · 2021Article
- Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell.Pharmaceutics · 2020Review
- A Multiparametric Study of Internalization of Fullerenol CInternational journal of molecular sciences · 2020Article
- CNano-micro letters · 2019Article
- CPharmaceutics · 2019Article
- Synergy of Chemo- and Photodynamic Therapies with CNanomaterials (Basel, Switzerland) · 2019Article
- Interactions of nanomaterials with ion channels and related mechanisms.British journal of pharmacology · 2019Review
- Complexation with CNanoscale research letters · 2019Article
- Dependence of fullerene aggregation on lipid saturation due to a balance between entropy and enthalpy.Scientific reports · 2019Article
- CNanoscale research letters · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
There continues to be a significant increase in the number and complexity of hydrophobic nanomaterials that are engineered for a variety of commercial purposes making human exposure a significant health concern. This study uses a combination of biophysical, biochemical and computational methods to probe potential mechanisms for uptake of C60 nanoparticles into various compartments of living immune cells. Cultures of RAW 264.7 immortalized murine macrophage were used as a canonical model of immune-competent cells that are likely to provide the first line of defense following inhalation. Modes of entry studied were endocytosis/pinocytosis and passive permeation of cellular membranes. The evidence suggests marginal uptake of C60 clusters is achieved through endocytosis/pinocytosis, and that passive diffusion into membranes provides a significant source of biologically-available nanomaterial. Computational modeling of both a single molecule and a small cluster of fullerenes predicts that low concentrations of fullerenes enter the membrane individually and produce limited perturbation; however, at higher concentrations the clusters in the membrane causes deformation of the membrane. These findings are bolstered by nuclear magnetic resonance (NMR) of model membranes that reveal deformation of the cell membrane upon exposure to high concentrations of fullerenes. The atomistic and NMR models fail to explain escape of the particle out of biological membranes, but are limited to idealized systems that do not completely recapitulate the complexity of cell membranes. The surprising contribution of passive modes of cellular entry provides new avenues for toxicological research that go beyond the pharmacological inhibition of bulk transport systems such as pinocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.