ArticleCellular and molecular gastroenterology and hepatology2016
Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal Colon.
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Article in Cellular and molecular gastroenterology and hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
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23 citing papers in PubMed, 32 citations in OpenAlex.
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- Restoration of the lamina propria duodenal immune infiltrate in gluten-free diet treated celiac patients despite persistent villous atrophy.Clinical and experimental immunology · 2025Article
- Complex immune network and regional consistency in the human gastric mucosa revealed by high-resolution spectral cytometry.Scientific reports · 2024Article
- Effects of Golimumab and Ustekinumab on Circulating Dendritic Cell Migratory Capacity in Inflammatory Bowel Disease.Biomedicines · 2023Article
- Differential Effects of Anti-TNFα and Anti-α4β7 Drugs on Circulating Dendritic Cells Migratory Capacity in Inflammatory Bowel Disease.Biomedicines · 2022Article
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- Identification of CX3CR1iScience · 2022Article
- Dendritic Cell-Targeted Therapies to Treat Neurological Disorders.Molecular neurobiology · 2022Review
- Inherent Immune Cell Variation Within Colonic Segments Presents Challenges for Clinical Trial Design.Journal of Crohn's & colitis · 2020Article
- Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease.Microbiome · 2020Article
- Deficient Resident Memory T Cell and CD8 T Cell Response to Commensals in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2020Article
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- Changes in neuromuscular structure and functions of human colon during ageing are region-dependent.Gut · 2019Article
- Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer.European journal of nutrition · 2019Article
- Two distinct colonic CD14Mucosal immunology · 2019Article
- Human intestinal pro-inflammatory CD11cMucosal immunology · 2018Article
- To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis.Journal of neuropathology and experimental neurology · 2018Review
- The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease.Inflammatory bowel diseases · 2018Article
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Authors and funding
30 authors at 12 institutions in 4 countries.
David BernardoAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom.
Lydia DurantAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom.
Elizabeth R MannAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Elizabeth BassityGut Health and Food Safety Programme, Institute of Food Research, Norwich, United Kingdom.
Enrique MontalvilloMucosal Immunology Group, Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid-CSIC, Valladolid, Spain.
Ripple ManSt. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Rakesh VoraAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Durga ReddiAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom.
Fahri BayirogluDepartment of Physiology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey; Faculty of Farmacy, Agri İbrahim Cecen University, Agri, Turkey.
Luis Fernández-SalazarGastroenterology Service, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Nick R EnglishAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom.
Simon T C PeakeAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Jon LandyAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Gui H LeeAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
George MalietzisAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Yi Harn SiawAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Aravinth U MurugananthanAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Phil HendyAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom; St. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Eva Sánchez-RecioAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom.
Robin K S PhillipsSt. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Jose A GarroteMucosal Immunology Group, Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid-CSIC, Valladolid, Spain; Genetics and Molecular Biology Department, Clinical Laboratory Service, Hospital Universitario Rio Hortega, Valladolid, Spain.
Paul ScottPathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Julian ParkhillPathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Malte PaulsenNational Heart and Lung Institute, Imperial College London, London.
Ailsa L HartSt. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Hafid O Al-HassiAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom.
Eduardo ArranzSt. Mark's Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom.
Alan W WalkerPathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom; Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom.
Simon R CardingGut Health and Food Safety Programme, Institute of Food Research, Norwich, United Kingdom; Norwich Medical School, University of East Anglia, Norwich, United Kingdom.
Stella C KnightAntigen Presentation Research Group, Imperial College London, Harrow, United Kingdom.
Imperial College London · GBLondon North West Healthcare NHS Trust · GBSt Mark's Hospital · GBWellcome Sanger Institute · GBAnkara Yıldırım Beyazıt University · TRHospital Clínico Universitario de Valladolid · ESInstituto de Biomedicina y Genética Molecular de Valladolid · ESQuadram Institute · GBUniversidad de Valladolid · ESUniversity of Aberdeen · GBUniversity of East Anglia · GBUniversity of Glasgow · GB
Funding
BASIC SCIENCE RESEARCH IN DIGESTIVE DISEASEST32DK007632 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 1989 to 2018
$5.4MNIDDK NIH HHS T32 DK007632Wellcome TrustWorldwide Cancer Research 12-0234
Abstract
BACKGROUND &
aimsMost knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103
methodsPaired proximal (right/ascending) and distal (left/descending) human colonic biopsies from 95 healthy subjects were taken; DC were assessed by flow cytometry and microbiota composition assessed by 16S rRNA gene sequencing.
resultsColonic DC identified were myeloid (mDC, CD11c
conclusionsProximal colonic DC subsets differ from those in distal colon and are more mature. Targeted immunotherapy using DC in T-cell mediated GI tract inflammation may therefore need to reflect this immune compartmentalization.
Indexed as
AMOVA, analysis of molecular varianceCCL, chemokine (C-C motif) ligandCCR2CCR, chemokine (C-C motif) receptorCFSE, 5-carboxy fluorescein diacetate succinimidyl esterDC, dendritic cellsDendritic CellsDistal ColonDL, detection limitFACS, fluorescence-activated cell sortingFITC, fluorescein isothiocyanateGI, gastrointestinalHuman Gastrointestinal TractIL, interleukinILT3, Ig-like transcript 3LPMC, lamina propria mononuclear cellsmDC, myeloid dendritic cellMicrobiotaMφ, macrophagesPBMC, peripheral blood mononuclear cellsPCR, polymerase chain reactionpDC, plasmacytoid dendritic cellProximal ColonRALDH2, retinaldehyde dehydrogenase type 2SIRPα, signal regulatory protein αSPB, sodium phosphate bufferTreg, regulatory T-cells
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