ReviewBiomicrofluidics2016
In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications.
Review in Biomicrofluidics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Circulating Bubbles in Decompression Sickness: Pathophysiology and Experimental Models.Biomolecules · 2026Review
- Cyclic jetting enables microbubble-mediated drug delivery.Nature physics · 2025Article
- Analysis of Microbubble-Blood cell system Oscillation/Cavitation influenced by ultrasound Forces: Conjugate applications of FEM and LBM.Ultrasonics sonochemistry · 2024Article
- Exploring Different Ultrasonic Parameters and Treatment Conditions to Optimize In Vitro Sonodynamic Therapeutic Effects in Cancer Cells.Cell biochemistry and biophysics · 2024Article
- Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers.BMC pharmacology & toxicology · 2024Article
- Protein-Decorated Microbubbles for Ultrasound-Mediated Cell Surface Manipulation.ACS applied bio materials · 2023Article
- Acoustofluidic Interfaces for the Mechanobiological Secretome of MSCs.Nature communications · 2023Article
- An Acoustic Device for Ultra High-Speed Quantification of Cell Strain During Cell-Microbubble Interaction.ACS biomaterials science & engineering · 2023Article
- The role of acoustofluidics and microbubble dynamics for therapeutic applications and drug delivery.Biomicrofluidics · 2023Review
- Water-Sulfuric Acid Foam as a Possible Habitat for Hypothetical Microbial Community in the Cloud Layer of Venus.Life (Basel, Switzerland) · 2021Article
- Sonoporation Using Nanoparticle-Loaded Microbubbles Increases Cellular Uptake of Nanoparticles Compared to Co-Incubation of Nanoparticles and Microbubbles.Pharmaceutics · 2021Article
- Ultrasound-induced molecular delivery to erythrocytes using a microfluidic system.Biomicrofluidics · 2020Article
- Sonoporation of Cells by a Parallel Stable Cavitation Microbubble Array.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018Article
- Layered acoustofluidic resonators for the simultaneous optical and acoustic characterisation of cavitation dynamics, microstreaming, and biological effects.Biomicrofluidics · 2018Article
- Quantification of cell-bubble interactions in a 3D engineered tissue phantom.Scientific reports · 2017Article
- Synergy of Microfluidics and Ultrasound : Process Intensification Challenges and Opportunities.Topics in current chemistry (Cham) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides their use as contrast agents for ultrasound imaging, microbubbles are increasingly studied for a wide range of therapeutic applications. In particular, their ability to enhance the uptake of drugs through the permeabilization of tissues and cell membranes shows great promise. In order to fully understand the numerous paths by which bubbles can interact with cells and the even larger number of possible biological responses from the cells, thorough and extensive work is necessary. In this review, we consider the range of experimental techniques implemented in in vitro studies with the aim of elucidating these microbubble-cell interactions. First of all, the variety of cell types and cell models available are discussed, emphasizing the need for more and more complex models replicating in vivo conditions together with experimental challenges associated with this increased complexity. Second, the different types of stabilized microbubbles and more recently developed droplets and particles are presented, followed by their acoustic or optical excitation methods. Finally, the techniques exploited to study the microbubble-cell interactions are reviewed. These techniques operate over a wide range of timescales, or even off-line, revealing particular aspects or subsequent effects of these interactions. Therefore, knowledge obtained from several techniques must be combined to elucidate the underlying processes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.