ArticleGenomics & informatics2015
Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans.
Article in Genomics & informatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Immune Checkpoint Inhibitor-related Endocrinopathies.Journal of translational internal medicine · 2022Article
- Association of HLA-DRB1 and -DQB1 Alleles with Susceptibility to IgA Nephropathy in Korean Patients.Annals of laboratory medicine · 2022Article
- Prevalence and clinical characteristics of fulminant type 1 diabetes mellitus in Korean adults: A multi-institutional joint research.Journal of diabetes investigation · 2022Article
- Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.PLoS genetics · 2019Article
- A Case of Fulminant Type 1 Diabetes with Gastric and Urinary Retention.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Article
- A Case of Fulminant Type 1 Diabetes in a Patient with Type 2 Diabetes Mellitus.Journal of obesity & metabolic syndrome · 2017Article
- Fulminant Type 1 Diabetes in Children: A Multicenter Study in China.Journal of diabetes research · 2017Article
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Authors and funding
9 authors.
Funding
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Abstract
Fulminant type 1 diabetes (T1DM) is a distinct subtype of T1DM that is characterized by rapid onset hyperglycemia, ketoacidosis, absolute insulin deficiency, and near normal levels of glycated hemoglobin at initial presentation. Although it has been reported that class II human leukocyte antigen (HLA) genotype is associated with fulminant T1DM, the genetic predisposition is not fully understood. In this study we investigated the HLA genotype and haplotype in 11 Korean cases of fulminant T1DM using imputation of whole exome sequencing data and compared its frequencies with 413 participants of the Korean Reference Panel. The HLA-DRB1*04:05-HLA-DQB1*04:01 haplotype was significantly associated with increased risk of fulminant T1DM in Fisher's exact test (odds ratio [OR], 4.11; 95% confidence interval [CI], 1.56 to 10.86; p = 0.009). A histidine residue at HLA-DRβ1 position 13 was marginally associated with increased risk of fulminant T1DM (OR, 2.45; 95% CI ,1.01 to 5.94; p = 0.054). Although we had limited statistical power, we provide evidence that HLA haplotype and amino acid change can be a genetic risk factor of fulminant T1DM in Koreans. Further large-scale research is required to confirm these findings.
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