Evidence map›Paper›PMID 26865518›Full record

Trial reportNeurology2016

Age at onset and Parkinson disease phenotype.

Gennaro Pagano, Nicola Ferrara, David J Brooks, Nicola Pavese

Registry-linked trialAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06174740 (Neural Correlates of Multisensory Stimulation in Healthy Older Adults), which is not on this map. Cited by 195 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06174740 nacompletednot on this mapstarted 2023, after this paper: background citation

Neural Correlates of Multisensory Stimulation in Healthy Older Adults

TypeinterventionalSponsorUniversiteit LeidenRan2023 to 2024Enrolled50ConditionsAging, Music, Motor Activity, Magnetic Resonance ImagingArmsMusic-cued audiovisual motor training, Visually-cued motor training
3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  10. Extreme heat and hospitalization with Parkinson's disease among older adults.Journal of exposure science & environmental epidemiology · 2026
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  11. Prevalence and state-dependent patterns of non-motor fluctuations in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Gennaro PaganoFrom the Department of Medicine (G.P., D.J.B., N.P.), Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, London, UK; Department of Translational Medical Sciences (G.P., N.F.), Federico II University of Naples; Salvatore Maugeri Foundation (N.F.), IRCCS, Scientific Institute of Telese, Telese Terme (BN), Italy; and Department of Clinical Medicine-Center for Functionally Integrative Neuroscience (D.J.B., N.P.), Aarhus University, Denmark.
Nicola FerraraFrom the Department of Medicine (G.P., D.J.B., N.P.), Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, London, UK; Department of Translational Medical Sciences (G.P., N.F.), Federico II University of Naples; Salvatore Maugeri Foundation (N.F.), IRCCS, Scientific Institute of Telese, Telese Terme (BN), Italy; and Department of Clinical Medicine-Center for Functionally Integrative Neuroscience (D.J.B., N.P.), Aarhus University, Denmark.
David J BrooksFrom the Department of Medicine (G.P., D.J.B., N.P.), Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, London, UK; Department of Translational Medical Sciences (G.P., N.F.), Federico II University of Naples; Salvatore Maugeri Foundation (N.F.), IRCCS, Scientific Institute of Telese, Telese Terme (BN), Italy; and Department of Clinical Medicine-Center for Functionally Integrative Neuroscience (D.J.B., N.P.), Aarhus University, Denmark.
Nicola PaveseFrom the Department of Medicine (G.P., D.J.B., N.P.), Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, London, UK; Department of Translational Medical Sciences (G.P., N.F.), Federico II University of Naples; Salvatore Maugeri Foundation (N.F.), IRCCS, Scientific Institute of Telese, Telese Terme (BN), Italy; and Department of Clinical Medicine-Center for Functionally Integrative Neuroscience (D.J.B., N.P.), Aarhus University, Denmark. nicola.pavese@imperial.ac.uk.

Funding

Medical Research Council G1100810Medical Research Council MC_U120036861
6 · The paper itself

Abstract

objectiveTo explore clinical phenotype and characteristics of Parkinson disease (PD) at different ages at onset in recently diagnosed patients with untreated PD.

methodsWe have analyzed baseline data from the Parkinson's Progression Markers Initiative database. Four hundred twenty-two patients with a diagnosis of PD confirmed by DaTSCAN imaging were divided into 4 groups according to age at onset (onset younger than 50 years, 50-59 years, 60-69 years, and 70 years or older) and investigated for differences in side, type and localization of symptoms, occurrence/severity of motor and nonmotor features, nigrostriatal function, and CSF biomarkers.

resultsOlder age at onset was associated with a more severe motor and nonmotor phenotype, a greater dopaminergic dysfunction on DaTSCAN, and reduction of CSF α-synuclein and total tau. The most common presentation was the combination of 2 or 3 motor symptoms (bradykinesia, resting tremor, and rigidity) with rigidity being more common in the young-onset group. In about 80% of the patients with localized onset, the arm was the most affected part of the body, with no difference across subgroups.

conclusionsAlthough the presentation of PD symptoms is similar across age subgroups, the severity of motor and nonmotor features, the impairment of striatal binding, and the levels of CSF biomarkers increase with age at onset. The variability of imaging and nonimaging biomarkers in patients with PD at different ages could hamper the results of future clinical trials.

Indexed as

AgedAge of Onsetalpha-SynucleinAmyloid beta-PeptidesBiomarkersCaudate NucleusDatabases, FactualFemaleFunctional LateralityHumansMaleMiddle AgedParkinson DiseasePeptide FragmentsPhenotypePhosphorylationalpha-SynucleinAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersMAPT protein, humanPeptide FragmentsSNCA protein, humantau ProteinsUric Acid

Identifiers

PMID26865518
PMCPMC4831034

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.