ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Analysis in vivo using a new method, ARGO (Analysis of Red-Green Offset), reveals complexity and cell-type specificity in presynaptic turnover of synaptic vesicle protein Synaptogyrin/SNG-1.Molecular biology of the cell · 2026Article
- Multilayered regulation of longevity in Caenorhabditis elegans.Molecules and cells · 2026Review
- AnalysisbioRxiv : the preprint server for biology · 2025Article
- Protein Translation Rates Are Negatively Correlated With Lifespan in Inbred Drosophila Strains.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Timing of TORC1 inhibition dictates Pol III involvement inLife science alliance · 2024Article
- Human wild-type and D76N βFASEB bioAdvances · 2023Article
- Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling.Nature communications · 2023Article
- Capillary electrophoresis-mass spectrometry as a tool for Caenorhabditis elegans metabolomics research.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Protein translation paradox: Implications in translational regulation of aging.Frontiers in cell and developmental biology · 2023Review
- G-quadruplexes and associated proteins in aging and Alzheimer's disease.Frontiers in aging · 2023Review
- Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling inMolecules and cells · 2022Review
- Axenic Culture ofInternational journal of molecular sciences · 2022Article
- A heterotypic assembly mechanism regulates CHIP E3 ligase activity.The EMBO journal · 2022Article
- Article
- Insights Into the Links Between Proteostasis and Aging FromFrontiers in aging · 2022Review
- Elevated Trehalose Levels inMetabolites · 2021Article
- Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.Molecular & cellular proteomics : MCP · 2021Review
- Proteostasis is adaptive: Balancing chaperone holdases against foldases.PLoS computational biology · 2020Article
- AMPK-mediated formation of stress granules is required for dietary restriction-induced longevity in Caenorhabditis elegans.Aging cell · 2020Article
- Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity.Proteomics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In Caenorhabditis elegans, cellular proteostasis is likely essential for longevity. Autophagy has been shown to be essential for lifespan extension of daf-2 insulin/IGF mutants. Therefore, it can be hypothesized that daf-2 mutants achieve this phenotype by increasing protein turnover. However, such a mechanism would exert a substantial energy cost. By using classical
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.