Evidence map›Paper›PMID 26865404›Full record

ArticleArtificial DNA, PNA & XNA2014

Effect of 2'-O-methyl/thiophosphonoacetate-modified antisense oligonucleotides on huntingtin expression in patient-derived cells.

Masayuki Matsui, Richard N Threlfall, Marvin H Caruthers, David R Corey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial DNA, PNA & XNA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Masayuki Matsuia Department of Pharmacology; UT Southwestern Medical Center ; Dallas , TX USA.
Richard N Threlfallb Department of Chemistry and Biochemistry ; University of Colorado at Boulder ; Boulder , CO USA.
Marvin H Caruthersb Department of Chemistry and Biochemistry ; University of Colorado at Boulder ; Boulder , CO USA.
David R Coreya Department of Pharmacology; UT Southwestern Medical Center ; Dallas , TX USA.
University of Colorado Boulder · USSouthwestern Medical CenterThe University of Texas Southwestern Medical Center · US

Funding

Recognition of Chromosomal DNA by Peptide Nucleic AcidsR01GM073042 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI COREY, DAVID R · 2005 to 2016
$3.5M
NIGMS NIH HHS GM 73042
6 · The paper itself

Abstract

Optimizing oligonucleotides as therapeutics will require exploring how chemistry can be used to enhance their effects inside cells. To achieve this goal it will be necessary to fully explore chemical space around the native DNA/RNA framework to define the potential of diverse chemical modifications. In this report we examine the potential of thiophosphonoacetate (thioPACE)-modified 2'-O-methyl oligoribonucleotides as inhibitors of human huntingtin (HTT) expression. Inhibition occurred, but was less than with analogous locked nucleic acid (LNA)-substituted oligomers lacking the thioPACE modification. These data suggest that thioPACE oligonucleotides have the potential to control gene expression inside cells. However, advantages relative to other modifications were not demonstrated. Additional modifications are likely to be necessary to fully explore any potential advantages of thioPACE substitutions.

Indexed as

AnimalsCells, CulturedDNAHumansHuntingtin ProteinHuntington DiseaseMiceOligonucleotidesOligonucleotides, AntisenseOrganothiophosphorus CompoundsRNADNAHTT protein, humanHuntingtin Proteinlocked nucleic acidOligonucleotidesOligonucleotides, AntisenseOrganothiophosphorus CompoundsRNAantisense oligonucleotideshuntingtinHuntington's diseaselocked nucleic acidsphosphate modificationthiophosphonoacetate

Identifiers

PMID26865404
PMCPMC5329896
OpenAlexW2282461061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.