ArticleScientific reports2016
Iron stimulates plasma-activated medium-induced A549 cell injury.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 85 citations in OpenAlex.
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- Rhodamine-based Fluorescent Probe With Quick Response and High Selectivity for Imaging Labile Ferrous Iron in Living Cells and Zebrafish.Journal of fluorescence · 2025Article
- Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway.Journal of clinical biochemistry and nutrition · 2024Article
- Medical gas plasma technology: Roadmap on cancer treatment and immunotherapy.Redox biology · 2023Review
- Emerging innovations in cold plasma therapy against cancer: A paradigm shift.Drug discovery today · 2022Review
- Preclinical Cold Atmospheric Plasma Cancer Treatment.Cancers · 2022Review
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- The Quest to Quantify Selective and Synergistic Effects of Plasma for Cancer Treatment: Insights from Mathematical Modeling.International journal of molecular sciences · 2021Article
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- Ability of plasma-activated acetated Ringer's solution to induce A549 cell injury is enhanced by a pre-treatment with histone deacetylase inhibitors.Journal of clinical biochemistry and nutrition · 2020Article
- Plasma-activated medium as adjuvant therapy for lung cancer with malignant pleural effusion.Scientific reports · 2020Article
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- Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer.EBioMedicine · 2020Article
- Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments.Cancers · 2019Review
- The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells.Cell death & disease · 2019Article
- The Interrelationship of Pharmacologic Ascorbate Induced Cell Death and Ferroptosis.Pathology oncology research : POR · 2019Article
- Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.Journal of neurochemistry · 2018Article
- Development of Chemical Tools for Imaging of Fe(II) Ions in Living Cells: A Review.Acta histochemica et cytochemica · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-thermal atmospheric pressure plasma is applicable to living cells and has emerged as a novel technology for cancer therapy. Plasma has recently been shown to affect cells not only by direct irradiation, but also by indirect treatments with previously prepared plasma-activated medium (PAM). Iron is an indispensable element but is also potentially toxic because it generates the hydroxyl radical (•OH) in the presence of hydrogen peroxide (H2O2) via the Fenton reaction. The aim of the present study was to demonstrate the contribution of iron to PAM-induced A549 adenocarcinoma cell apoptosis. We detected the generation of •OH and elevation of intracellular ferrous ions in PAM-treated cells and found that they were inhibited by iron chelator. The elevations observed in ferrous ions may have been due to their release from the intracellular iron store, ferritin. Hydroxyl radical-induced DNA injury was followed by the activation of poly(ADP-ribose) polymerase-1, depletion of NAD(+) and ATP, and elevations in intracellular Ca(2+). The sensitivities of normal cells such as smooth muscle cells and keratinocytes to PAM were less than that of A549 cells. These results demonstrated that H2O2 in PAM and/or •OH generated in the presence of iron ions disturbed the mitochondrial-nuclear network in cancer cells.
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