Evidence map›Paper›PMID 26865259›Full record

ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2016

Pre-Operative Cognitive Functioning and Inflammatory and Neuroendocrine Responses to Cardiac Surgery.

Lydia Poole, Amy Ronaldson, Tara Kidd, Elizabeth Leigh, Marjan Jahangiri, Andrew Steptoe

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lydia PooleDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK. lydia.poole.09@ucl.ac.uk.
Amy RonaldsonDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Tara KiddDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Elizabeth LeighDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Marjan JahangiriDepartment of Cardiac Surgery, St George's Hospital, University of London, Blackshaw Road, London, SW17 0QT, UK.
Andrew SteptoeDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
University College London · GBUniversity of London · GB

Funding

British Heart Foundation FS/09/049/27874British Heart Foundation FS/13/40/30343British Heart Foundation RG/10/005/28296
6 · The paper itself

Abstract

backgroundCognitive functioning is linked to cardiac mortality and morbidity, but the mechanisms underlying this relationship are unclear. PURPOSE: To examine the relationship between pre-operative cognitive functioning and post-operative inflammatory and neuroendocrine responses in patients undergoing coronary artery bypass graft (CABG) surgery.

methodsOne-hundred ninety-three outpatients were screened to assess their cognitive function using the Montreal Cognitive Assessment (MoCA) on average 30 days prior to CABG surgery and provided blood samples for the measurement of interleukin (IL)-6 and C-reactive protein (CRP) and saliva samples for the measurement of diurnal cortisol. Participants were followed-up 4-8 days following surgery for the repeat measurement of IL-6 and CRP and 60 days after surgery for the measurement of diurnal salivary cortisol.

resultsPatients with low cognitive function (MoCA < 26) prior to surgery reached higher IL-6 concentrations in the days after surgery (β = -0.212, p = 0.021) and had greater cortisol output across the day 2 months after surgery (β = -0.179, p = 0.044).

conclusionsLow cognitive functioning is associated with a more negative pattern of biological response to surgery, indicative of poorer physical recovery. These pathways may contribute to the links between cognitive function and cardiovascular pathology.

Indexed as

CognitionAgedCoronary Artery BypassC-Reactive ProteinFemaleHumansHydrocortisoneInterleukin-6MalePostoperative PeriodPreoperative PeriodSalivaC-Reactive ProteinHydrocortisoneIL6 protein, humanInterleukin-6CognitionCoronary artery bypass graft surgeryCortisolInflammation

Identifiers

PMID26865259
PMCPMC4933739
OpenAlexW2255079506

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.