Evidence map›Paper›PMID 26865244›Full record

ArticleAmerican journal of physical anthropology2016

Cortical bone histomorphology of known-age skeletons from the Kirsten collection, Stellenbosch university, South Africa.

Susan Pfeiffer, Jarred Heinrich, Amy Beresheim, Mandi Alblas

Open access · hybridAbstract read
In one paragraph

Article in American journal of physical anthropology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
32.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Susan PfeifferDepartment of Anthropology, University of Toronto, Toronto, M5S 2S2, Canada.
Jarred HeinrichDepartment of Anthropology, University of Toronto, Toronto, M5S 2S2, Canada.
Amy BeresheimDepartment of Anthropology, University of Toronto, Toronto, M5S 2S2, Canada.
Mandi AlblasDepartment of Biomedical Sciences, University of Stellenbosch, Cape Town, South Africa 8000.
University of Toronto · CAStellenbosch University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNormal human bone tissue changes predictably as adults get older, but substantial variability in pattern and pace remains unexplained. Information is needed regarding the characteristics of histological variables across diverse human populations.

methodsUndecalcified thin sections from mid-thoracic ribs of 213 skeletons (138 M, 75 F, 17-82 years, mean age 48 years), are used to explore the efficacy of an established age-at-death estimation method and methodological approach (Cho et al.: J Forensic Sci 47 (2002) 12-18) and expand on it. The ribs are an age-balanced sample taken from skeletonized cadavers collected from 1967 to 1999 in South Africa, each with recorded sex, age, cause of death and government-defined population group (129 "Colored," 49 "Black," 35 "White").

resultsThe Ethnicity Unknown equation performs better than those developed for European-Americans and African-Americans, in terms of accuracy and bias. A new equation based solely on the study sample does not improve accuracy. Osteon population densities (OPD) show predicted values, yet secondary osteon areas (On.Ar) are smaller than expected for non-Black subgroups. Relative cortical area (Ct.Ar/Tt.Ar) is low among non-Whites.

conclusionsResults from this highly diverse sample show that population-specific equations do not increase estimate precision. While within the published range of error for the method (±24.44 years), results demonstrate a systematic under-aging of young adults and over-aging of older adults. The regression approach is inappropriate. The field needs fresh approaches to statistical treatment and to factors behind cortical bone remodeling.

Indexed as

AdolescentAdultAgedAged, 80 and overAge Determination by SkeletonAgingAnthropology, PhysicalBlack or African AmericanBlack PeopleBone RemodelingCortical BoneFemaleHumansMaleMiddle AgedSouth Africaage-at-death estimationbone massbone remodelinghistologyWestern Cape

Identifiers

PMID26865244
PMCPMC5067612
OpenAlexW2265394071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.