Evidence map›Paper›PMID 26865200›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2016

Patterns and Correlates of Baseline Thiazide-Type Diuretic Prescription in the Systolic Blood Pressure Intervention Trial.

Tara I Chang, Gregory Evans, Alfred K Cheung, William C Cushman, Matthew J Diamond, Jamie P Dwyer, Yonghong Huan, Dalane Kitzman, John B Kostis, Suzanne Oparil and 8 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Hydrochlorothiazide Is America's Most Popular Thiazide, But Should It Be?Journal of the American Heart Association · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Non-Adherence to Antihypertensive Guidelines in Patients with Asymptomatic Carotid Stenosis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Tara I ChangFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.). tichang@stanford.edu.
Gregory EvansFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Alfred K CheungFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
William C CushmanFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Matthew J DiamondFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Jamie P DwyerFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Yonghong HuanFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Dalane KitzmanFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
John B KostisFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Suzanne OparilFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Anjay RastogiFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Christianne L RoumieFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Rukmani SahayFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Randall S StaffordFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Addison A TaylorFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Jackson T WrightFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
Glenn M ChertowFrom the Division of Nephrology (T.I.C., R.S., G.M.C.) and Stanford Prevention Research Center (R.S.S.), Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Departments of Biostatistical Sciences (G.E.) and Internal Medicine (D.K.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C.); Medical Service, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Department of Medicine, The Medical College of Georgia, Georgia Regents University, Augusta (M.J.D.); Division of Nephrology and Hypertension, Department of Medicine (J.P.D.) and Department of General Internal Medicine and Public Health (C.L.R.), Vanderbilt University, Nashville, TN ; Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia (Y.H.); Departments of Medicine and Pharmacology, Robert Wood Johnson Medical School, New Brunswick, NJ (J.B.K.); Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.O.); Department of Medicine, University of California, Los Angeles (A.R.); VA Tennessee Valley Healthcare System Geriatrics Research and Education Clinical Center (GRECC), Nashville (C.L.R.); Medical Care Line, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.A.T.); and Department of Medicine, Case Western Reserve University, Cleveland, OH (J.T.W.).
SPRINT Study Research Group
Wake Forest University · US

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Tufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4M
University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025771 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2008 to 2011
$17.6M
NCATS NIH HHS 9U54TR000017-06NCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1TR000003NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1TR000005NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1TR000050NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000073NCATS NIH HHS UL1TR000073NCATS NIH HHS UL1 TR000075NCATS NIH HHS UL1TR000075NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1TR000093NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1TR000105-05NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001064NCATS NIH HHS UL1TR001064NCATS NIH HHS UL1 TR001070NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR001427NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1RR024134NCRR NIH HHS UL1 RR025752NCRR NIH HHS UL1RR025752NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1RR025755NCRR NIH HHS UL1 RR025771NCRR NIH HHS UL1RR025771NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNIDDK NIH HHS K23 DK095914NIGMS NIH HHS P30 GM103337NIGMS NIH HHS P30GM103337
6 · The paper itself

Abstract

Thiazides and thiazide-type diuretics are recommended as first-line agents for the treatment of hypertension, but contemporary information on their use in clinical practice is lacking. We examined patterns and correlates of thiazide prescription in a cross-sectional analysis of baseline data from participants enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT). We examined baseline prescription of thiazides in 7582 participants receiving at least 1 antihypertensive medication by subgroup, and used log-binomial regression to calculate adjusted prevalence ratios for thiazide prescription (versus no thiazide). Forty-three percent of all participants were prescribed a thiazide at baseline, but among participants prescribed a single agent, the proportion was only 16%. The prevalence of thiazide prescription differed significantly by demographic factors, with younger participants, women, and blacks all having higher adjusted prevalence of thiazide prescription than other corresponding subgroups. Participants in the lowest category of kidney function (estimated glomerular filtration rate <30 mL/min per 1.73 m2) were half as likely to be prescribed a thiazide as participants with preserved kidney function. In conclusion, among persons with hypertension and heightened cardiovascular risk, we found that thiazide prescription varied significantly by demographics and kidney disease status, despite limited evidence about relative differences in effectiveness.

Indexed as

Prescription DrugsAgedAged, 80 and overBlood PressureCross-Sectional StudiesFemaleFollow-Up StudiesHumansHypertensionMaleMiddle AgedRetrospective StudiesSodium Chloride Symporter InhibitorsSystoleTreatment OutcomePrescription DrugsSodium Chloride Symporter Inhibitorsantihypertensive agentsblood pressurehypertensionrisk factorsthiazides

Identifiers

PMID26865200
PMCPMC4755350
OpenAlexW2255642269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.