ArticleScientific reports2016
Calcium and Magnesium Ions Are Membrane-Active against Stationary-Phase Staphylococcus aureus with High Specificity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 112 citations in OpenAlex.
- Alanine Uptake Is Required to MaintainMicroorganisms · 2026Article
- The staphylococcal type VII secretion system protein EsxC impacts daptomycin sensitivity through controlling bacterial cell envelope integrity.Journal of bacteriology · 2026Article
- Optimized Microfluidic Synthesis of Magnesium Magnetic Silica-Based Aerogels for Pesticide Removal and Antimicrobial Water Treatment.International journal of molecular sciences · 2026Article
- Antimicrobial and Anti-Biofilm Properties of Ma'in Hot Springs Targeting Bacteria Isolated from Diabetic Foot Ulcers.Infection and drug resistance · 2026Article
- Magnesium Infusion on Dental Implants and Its Impact on Osseointegration and Biofilm Development: A Review.European journal of dentistry · 2025Article
- Article
- Evaluation of the interface of metallic-coated biodegradable polymeric stents with prokaryotic and eukaryotic cells.Bioactive materials · 2025Article
- PVP as an Oxygen Vacancy-Inducing Agent in the Development of Black 45S5 Bioactive Glass Fibrous Scaffolds Doped with Zn and Mg Using A-HSBS.Materials (Basel, Switzerland) · 2025Article
- In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite.Journal of functional biomaterials · 2025Article
- Lipid- and Multivariate-Based Analyses to Determine Cell Response to pH Variations and Buffer Composition.Marine biotechnology (New York, N.Y.) · 2025Article
- Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics.eLife · 2025Article
- Calcium hydroxide coating for orthopedic implants: evaluation of osseointegrative and antibacterial propertiesFrontiers in bioengineering and biotechnology · 2025Article
- Review
- Nanoarchitectonics of Bactericidal Coatings Based on CaCOACS applied bio materials · 2024Article
- In Vitro Characterization of Hydroxyapatite-Based Coatings Doped with Mg or Zn Electrochemically Deposited on Nanostructured Titanium.Biomimetics (Basel, Switzerland) · 2024Article
- Surface-modified titanium and titanium-based alloys for improved osteogenesis: A critical review.Heliyon · 2024Review
- Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections.PloS one · 2024Article
- New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites.Polymers · 2023Article
- Assessing the nonlinear association of environmental factors with antibiotic resistance genes (ARGs) in the Yangtze River Mouth, China.Scientific reports · 2023Article
- Harzianic Acid Activity againstToxins · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus (S. aureus) is notorious for its ability to acquire antibiotic-resistance, and antibiotic-resistant S. aureus has become a wide-spread cause of high mortality rate. Novel antimicrobials capable of eradicating S. aureus cells including antibiotic-resistant ones are thus highly desired. Membrane-active bactericides and species-specific antimicrobials are two promising sources of novel anti-infective agents for fighting against bacterial antibiotic-resistance. We herein show that Ca(2+) and Mg(2+), two alkaline-earth-metal ions physiologically essential for diverse living organisms, both disrupt model S. aureus membranes and kill stationary-phase S. aureus cells, indicative of membrane-activity. In contrast to S. aureus, Escherichia coli and Bacillus subtilis exhibit unaffected survival after similar treatment with these two cations, indicative of species-specific activity against S. aureus. Moreover, neither Ca(2+) nor Mg(2+) lyses mouse red blood cells, indicative of hemo-compatibility. This works suggests that Ca(2+) and Mg(2+) may have implications in targeted eradication of S. aureus pathogen including the antibiotic-resistant ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.