Evidence map›Paper›PMID 26865168›Full record

ReviewIndian journal of pediatrics2016

Application of Flow Cytometry in the Evaluation of Primary Immunodeficiencies.

Thomas A Fleisher, Manisha Madkaikar, Sergio D Rosenzweig

Abstract readReview
In one paragraph

Review in Indian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Inborn errors of immunity (primary immunodeficiencies).Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Considerations in the Diagnosis of Chronic Granulomatous Disease.Journal of the Pediatric Infectious Diseases Society · 2018
    Review
  13. Primary immunodeficiency.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas A FleisherDepartment of Laboratory Medicine, NIH Clinical Center, Building 10, Room 2C306, 10 Center Drive, MSC1508, Bethesda, MD, USA. tfleishe@mail.nih.gov.
Manisha MadkaikarDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), KEM Campus, Parel, Mumbai, India.
Sergio D RosenzweigDepartment of Laboratory Medicine, NIH Clinical Center, Building 10, Room 2C306, 10 Center Drive, MSC1508, Bethesda, MD, USA.

Funding

Lymphocytes In Autoimmune Lymphoproliferative SyndromeZ01CL010287 · CLC · CLINICAL CENTER · PI FLEISHER, THOMAS A · 1997 to 2008
$55k
Mutation Analysis Of Selected Lymphoid Immune DisordersZIACL010304 · CLC · CLINICAL CENTER · PI ROSENZWEIG, SERGIO · 2009 to 2025
$0k
Intramural NIH HHS Z01 CL010287
6 · The paper itself

Abstract

Primary immunodeficiency disorders (PIDDs) are a heterogeneous group of inherited disorders of the immune system. Currently more than 250 different PIDDs with a known genetic defect have been recognized. The diagnosis of many of these disorders is supported strongly by a wide variety of flow cytometry applications. Flow cytometry offers a rapid and sensitive tool for diagnosis and classification of PIDDs. It is applicable in the initial workup and subsequent management of several primary immunodeficiency diseases. As our understanding of the pathogenesis and management of these diseases increases, the majority of these tests can be easily established in the diagnostic laboratory. Thus, the focus of this article is on the application of flow cytometry in the diagnosis and/or evaluation of PIDDs.

Indexed as

Immunologic Deficiency SyndromesDisease ManagementFlow CytometryHumansReproducibility of ResultsDiagnosisFlow cytometryPrimary immunodeficiency

Identifiers

PMID26865168
PMCPMC5007620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.