Evidence map›Paper›PMID 26865105›Full record

ArticleAdvanced healthcare materials2016

Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.

Benjamin W Lee, Bohao Liu, Adam Pluchinsky, Nathan Kim, George Eng, Gordana Vunjak-Novakovic

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. One-Step 3D Printing of Heart Patches with Built-In Electronics for Performance Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  8. Mussel-inspired conductive TiTheranostics · 2020
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjamin W LeeLaboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Bohao LiuLaboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Adam PluchinskyLaboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Nathan KimLaboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
George EngLaboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Gordana Vunjak-NovakovicLaboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
Tissue Chips for Rare Disease: Adding Timothy Syndrome to the HeLIVaSkCa platformUH3EB017103 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2014 to 2016
$7.1M
Integrated heart-liver-vascular systems for drug testing in human health and diseUH2EB017103 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2012 to 2013
$1.7M
Biologically Inspired Engineering of Hierarchical Vascular NetworksF30HL112505 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ENG, GEORGE · 2012 to 2014
$117k
NHLBI NIH HHS F30 HL112505NHLBI NIH HHS HL076485NHLBI NIH HHS R01 HL076485NIBIB NIH HHS EB002520NIBIB NIH HHS EB17103NIBIB NIH HHS P41 EB002520NIBIB NIH HHS UH2 EB017103NIBIB NIH HHS UH3 EB017103NIGMS NIH HHS T32 GM007367
6 · The paper itself

Abstract

This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.

Indexed as

AnimalsAnisotropyEndothelial CellsEndothelium, VascularHeartMicrotechnologyMyocytes, CardiacNeovascularization, PhysiologicRatsTissue Engineeringanisotropycardiac tissue engineeringhydrogelsmicropatterningmodular assembly

Identifiers

PMID26865105
PMCPMC4836958

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.