ArticleRedox report : communications in free radical research2016
Reduced antioxidant capacity and increased subclinical inflammation markers in prepubescent obese children and their relationship with nutritional markers and metabolic parameters.
Article in Redox report : communications in free radical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03323294 (Bioenergetics and Metabolism in Pediatric Populations), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bioenergetics and Metabolism in Pediatric Populations
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association between the neutrophil-to-lymphocyte ratio and obstructive sleep apnea: a meta-analysis.Scientific reports · 2020Pooled it
- Association of serum total antioxidant capacity and uric acid with obesity and cardiometabolic traits in Mexican children.European journal of clinical nutrition · 2026Article
- Iron and Vitamin A Status of Children Aged 0 to 36 Months in Thulamela Municipality, Vhembe District, South Africa.Children (Basel, Switzerland) · 2024Article
- The Double-Edged Sword of Total Antioxidant Capacity: Clinical Significance and Personal Experience.Antioxidants (Basel, Switzerland) · 2024Review
- Association between biomarkers of redox status and cytokines with different patterns of habitual physical activity in eutrophic and overweight/obese preschoolers: multivariate analysis of a cross-sectional study.BMC public health · 2023Article
- Total Antioxidant Capacity in Obese and Non-Obese Subjects and Its Association with Anthropo-Metabolic Markers: Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2023Review
- The Impact of Physical Exercise on Obesity in a Cohort of Southern Italian Obese Children: Improvement in Cardiovascular Risk and Immune System Biomarkers.International journal of environmental research and public health · 2022Article
- Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status.Frontiers in nutrition · 2022Review
- Antitoxic Effects of Curcumin against Obesity-Induced Multi-Organs' Biochemical and Histopathological Abnormalities in an Animal Model.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Role of ferritin and oxidative stress index in gestational diabetes mellitus.Journal of diabetes and metabolic disorders · 2021Article
- Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study.Antioxidants (Basel, Switzerland) · 2021Article
- Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity.International journal of environmental research and public health · 2020Article
- Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status.Antioxidants (Basel, Switzerland) · 2020Article
- The Significance of Thiol/Disulfide Homeostasis and Ischemia-modified Albumin Levels in Assessing Oxidative Stress in Obese Children and AdolescentsJournal of clinical research in pediatric endocrinology · 2020Article
- Factors that influence the redox state in children: An exploratory study.Clinics (Sao Paulo, Brazil) · 2018Article
- Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age.PloS one · 2018Article
- Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers.Anatolian journal of cardiology · 2017Article
- One-year follow-up of clinical, metabolic and oxidative stress profile of morbid obese patients after laparoscopic sleeve gastrectomy. 8-oxo-dG as a clinical marker.Redox biology · 2017Article
- Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity.Oxidative medicine and cellular longevity · 2017Article
- Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People.Journal of obesity · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere are associations between some inflammatory and oxidative markers and obesity in adults, but whether prepubescent children of different weights also have such markers has not been studied. We investigated multiple inflammatory markers and levels of erythrocyte oxidant/antioxidant enzymes in prepubescent children of different weights.
methodsChildren aged 2-11 years were divided into three groups: 80 were underweight, 90 were obese but otherwise healthy, and 80 were healthy age- and sex-matched children of normal-weight. We analyzed inflammatory markers and the total oxidant status, total antioxidant status (TAS), and total thiol level were also determined, and the oxidative stress index was calculated as an indicator of the degree of oxidative stress.
resultsThe obese group exhibited higher levels of fasting glucose, insulin, total cholesterol, triglycerides, the homeostatic model assessment of insulin resistance (HOMA-IR), and the homeostatic model assessment of β-cell function (HOMA-β), C-reactive protein (CRP), neutrophils, and neutrophil/lymphocyte ratio (NLR), as well as lower TAS and total thiol levels than the other two groups (all P < 0.001). Moreover, TAS and total thiols were negatively correlated with age in the obese group (r = -0.212, P = 0.001; r = -0.231, P < 0.001, respectively). CRP levels in plasma were positively correlated with the body mass index (BMI), insulin and glucose levels, HOMA-IR, HOMA-β, WBC and neutrophil counts, and the NLR, and were negatively correlated with TAS and total thiol levels in the overall studied population. DISCUSSION: The coexistence of increased obesity-related subclinical inflammation and decreased antioxidant capacity can be observed even in prepubescence, and may eventually increase the risk of long-term vascular damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.