Evidence map›Paper›PMID 26864780›Full record

SynthesisHuman brain mapping2016

Coordinate-based (ALE) meta-analysis of brain activation in patients with fibromyalgia.

Mahboobeh Dehghan, Tobias Schmidt-Wilcke, Bettina Pfleiderer, Simon B Eickhoff, Frank Petzke, Richard E Harris, Pedro Montoya, Markus Burgmer

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 12 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 12 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Mahboobeh DehghanDepartment of Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany.
Tobias Schmidt-WilckeDepartment of Neurology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Ruhr Universität Bochum, Bochum, Germany.
Bettina PfleidererDepartment of Clinical Radiology, University Hospital Münster, Münster, Germany.
Simon B EickhoffInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Germany.
Frank PetzkeDepartment of Anesthesiology, Pain Medicine, University Hospital Göttingen, Göttingen, Germany.
Richard E HarrisDepartment of Anesthesiology, Chronic Pain and Fatigue Research, University of Michigan, Michigan.
Pedro MontoyaResearch Institute of Health Sciences, University of Balearic Islands, Palma, Spain.
Markus BurgmerDepartment of Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany.
University Hospital Münster · DEForschungszentrum Jülich · DEResearch Institute of Health Sciences · ESRuhr University Bochum · DEUniversitätsmedizin Göttingen · DEUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are an increasing number of neuroimaging studies that allow a better understanding of symptoms, neural correlates and associated conditions of fibromyalgia. However, the results of these studies are difficult to compare, as they include a heterogeneous group of patients, use different stimulation paradigms, tasks, and the statistical evaluation of neuroimaging data shows high variability. Therefore, this meta-analytic approach aimed at evaluating potential alterations in neuronal brain activity or structure related to pain processing in fibromyalgia syndrome (FMS) patients, using quantitative coordinate-based "activation likelihood estimation" (ALE) meta-analysis. 37 FMS papers met the inclusion criteria for an ALE analysis (1,264 subjects, 274 activation foci). A pooled ALE analysis of different modalities of neuroimaging and additional analyses according functional and structural changes indicated differences between FMS patients and controls in the insula, amygdala, anterior/mid cingulate cortex, superior temporal gyrus, the primary and secondary somatosensory cortex, and lingual gyrus. Our analysis showed consistent results across FMS studies with potential abnormalities especially in pain-related brain areas. Given that similar alterations have already been demonstrated in patients with other chronic pain conditions and the lack of adequate control groups of chronic pain subjects in most FMS studies, it is not clear however, whether these findings are associated with chronic pain in general or are unique features of patients with FMS. Hum Brain Mapp 37:1749-1758, 2016. © 2016 Wiley Periodicals, Inc.

Indexed as

Brain MappingBrainFemaleFibromyalgiaHumansImage Processing, Computer-AssistedMaleNeuroimagingactivation likelihood analysisbrain imagingdescending pain modulation systemfibromyalgiameta-analysispain

Identifiers

PMID26864780
PMCPMC6867581
OpenAlexW2254287137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.